PMID- 22873728
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20191112
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Nov
TI  - Human umbilical cord mesenchymal stem cell therapy on neuromyelitis optica.
PG  - 250-5
AB  - Stem cell transplantation is a promising therapy for neuromyelitis optica (NMO). 
      Among stem cell varieties, human umbilical cord-derived mesenchymal stem cells 
      (hUC-MSCs) possess many advantages, add a differential potential into neural 
      cells, secrete a set of trophic factors and cytokines, regulate immunological 
      function, and have therapeutic potential for neurological diseases. In this 
      study, hUC-MSCs transplantation was used to treat five NMO patients with 
      follow-up for 18 months including evaluation of Expanded Disability Status Scale 
      (EDSS) levels, clinical course, magnetic resonance imaging (MRI) characteristics, 
      adverse events, and so on. Among the five cases, four showed therapeutic 
      improvement after hUC-MSCs treatment. Both symptoms and signs improved and 
      relapse frequencies were reduced. MRI characteristics also showed decreased 
      volume and severity of lesions, while few adverse events occurred. The results 
      suggest that hUC-MSCs transplantation appear safe and might be effective for NMO 
      treatment in the near future. In addition, according to flow cytometry assay 
      (FACS) results, B cells of blood were inhibited while T cells increased after 
      treatment, indicating an immune-related mechanism.
FAU - Lu, Zhengjuan
AU  - Lu Z
AD  - Department of Neurology, Affiliated Drum Tower Hospital, Nanjing Medical 
      University, 321 Zhongshan Road, Nanjing, Jiangsu 210008, PR China.
FAU - Ye, Dan
AU  - Ye D
FAU - Qian, Lai
AU  - Qian L
FAU - Zhu, Lin
AU  - Zhu L
FAU - Wang, Chong
AU  - Wang C
FAU - Guan, Dening
AU  - Guan D
FAU - Zhang, Xiaoguang
AU  - Zhang X
FAU - Xu, Yun
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
SB  - IM
MH  - Adult
MH  - Female
MH  - Flow Cytometry
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Middle Aged
MH  - Neuromyelitis Optica/*pathology/*surgery
MH  - Umbilical Cord/*cytology
MH  - Young Adult
EDAT- 2012/08/10 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/07/12 00:00 [revised]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - CNR-EPUB-20120806-7 [pii]
AID - 10.2174/156720212803530708 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2012 Nov;9(4):250-5. doi: 10.2174/156720212803530708.