PMID- 22874763
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20240322
IS  - 1522-1466 (Electronic)
IS  - 1931-857X (Print)
IS  - 1522-1466 (Linking)
VI  - 303
IP  - 8
DP  - 2012 Oct 15
TI  - Activated CD47 regulates multiple vascular and stress responses: implications for 
      acute kidney injury and its management.
PG  - F1117-25
LID - 10.1152/ajprenal.00359.2012 [doi]
AB  - Ischemia-reperfusion injury (IRI) remains a significant source of early and 
      delayed renal transplant failure. Therapeutic interventions have yet to resolve 
      this ongoing clinical challenge although the reasons for this remain unclear. The 
      cell surface receptor CD47 is widely expressed on vascular cells and in tissues. 
      It has one known soluble ligand, the stress-released matricellular protein 
      thrombospondin-1 (TSP1). The TSP1-CD47 ligand receptor axis controls a number of 
      important cellular processes, inhibiting survival factors such as nitric oxide, 
      cGMP, cAMP, and VEGF, while activating injurious pathways such as production of 
      reactive oxygen species. A role of CD47 in renal IRI was recently revealed by the 
      finding that the TSP1-CD47 axis is induced in renal tubular epithelial cells 
      (RTEC) under hypoxia and following IRI. The absence of CD47 in knockout mice 
      increases survival, mitigates RTEC damage, and prevents subsequent kidney 
      failure. Conversely, therapeutic blockade of TSP1-CD47 signaling provides these 
      same advantages to wild-type animals. Together, these findings suggest an 
      important role for CD47 in renal IRI as a proximate promoter of injury and as a 
      novel therapeutic target.
FAU - Rogers, Natasha M
AU  - Rogers NM
AD  - Vascular Medicine Institute, University of Pittsburgh School of Medicine, 200 
      Lothrop St., Pittsburgh, PA 15261, USA.
FAU - Yao, Mingyi
AU  - Yao M
FAU - Novelli, Enrico M
AU  - Novelli EM
FAU - Thomson, Angus W
AU  - Thomson AW
FAU - Roberts, David D
AU  - Roberts DD
FAU - Isenberg, Jeffrey S
AU  - Isenberg JS
LA  - eng
GR  - K23 HL112848/HL/NHLBI NIH HHS/United States
GR  - 1P01HL103455-01/HL/NHLBI NIH HHS/United States
GR  - P01 HL103455/HL/NHLBI NIH HHS/United States
GR  - R01 HL-108954/HL/NHLBI NIH HHS/United States
GR  - R01 HL112914/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120808
PL  - United States
TA  - Am J Physiol Renal Physiol
JT  - American journal of physiology. Renal physiology
JID - 100901990
RN  - 0 (CD47 Antigen)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thrombospondin 1)
SB  - IM
MH  - Acute Kidney Injury/*metabolism/therapy
MH  - Animals
MH  - CD47 Antigen/*metabolism
MH  - Humans
MH  - Kidney/*metabolism
MH  - Mice
MH  - Reactive Oxygen Species/metabolism
MH  - Reperfusion Injury/metabolism
MH  - Thrombospondin 1/*metabolism
PMC - PMC3469673
EDAT- 2012/08/10 06:00
MHDA- 2013/01/12 06:00
PMCR- 2013/10/15
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
PHST- 2013/10/15 00:00 [pmc-release]
AID - ajprenal.00359.2012 [pii]
AID - F-00359-2012 [pii]
AID - 10.1152/ajprenal.00359.2012 [doi]
PST - ppublish
SO  - Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1117-25. doi: 
      10.1152/ajprenal.00359.2012. Epub 2012 Aug 8.