PMID- 22875171
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Feb
TI  - Myocardial fibrosis and quality of life in patients with non-ischemic 
      cardiomyopathy: a cardiovascular magnetic resonance imaging study.
PG  - 395-404
LID - 10.1007/s10554-012-0107-4 [doi]
AB  - Myocardial fibrosis (MF) is a common pathophysiologic endpoint in non-ischemic 
      cardiomyopathy and may be identified by late gadolinium enhancement (LGE) MRI. 
      While associated with future cardiovascular events in hypertrophic cardiomyopathy 
      (HCM) and dilated cardiomyopathy (DCM) the influence of MF on interim quality of 
      life (QOL) has not been explored. In this study we investigate for associations 
      between MF and validated indices of QOL in patients with HCM and DCM. 
      Ninety-eight patients with known cardiomyopathy (n = 56-HCM/n = 42-DCM) underwent 
      LGE-MRI in addition to standardized testing for QOL using the disease-specific 
      Minnesota Living With Heart Failure (MLWHF) and the generic SF-12 questionnaires. 
      LGE-MRI images were blindly analyzed for the presence and volume of MF using 
      validated techniques. All analyses were stratified according to cardiomyopathy 
      sub-type. The mean age of the population was 56.8 +/- 12.9 years. MF was identified 
      in 82 % of patients with HCM and 74 % of patients with DCM with respective mean 
      MF burdens of 20.0 and 13.7 % of the left ventricular mass (p = 0.008). QOL 
      scores for those with HCM or DCM, as assessed by both MLWHF and SF-12, were not 
      significantly different between those with versus those without MF, and showed no 
      association with MF burden by quantitative signal analysis. In this study we 
      identified no association between QOL and MF burden by LGE-MRI in patients with 
      HCM or DCM. Therefore, the severity of underlying myocardial tissue disease, a 
      recognized substrate for ventricular arrhythmia, cannot and should not be 
      inferred from the patient's symptom status or QOL.
FAU - Khan, Razi
AU  - Khan R
AD  - Division of Cardiology, Department of Medicine, Schulich School of Medicine and 
      Dentistry, Western University, 363 Colborne St., Suite 2503, London, ON, N6B 3N3, 
      Canada. razi.khan@gmail.com
FAU - Massel, David
AU  - Massel D
FAU - Stirrat, John
AU  - Stirrat J
FAU - Scholl, David
AU  - Scholl D
FAU - Wisenberg, Gerald
AU  - Wisenberg G
FAU - Thompson, Terry
AU  - Thompson T
FAU - Drangova, Maria
AU  - Drangova M
FAU - White, James A
AU  - White JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*diagnosis/pathology/psychology
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/pathology/psychology
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Quality of Life
MH  - Registries
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2012/08/10 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/05/29 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 10.1007/s10554-012-0107-4 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2013 Feb;29(2):395-404. doi: 10.1007/s10554-012-0107-4. 
      Epub 2012 Aug 9.