PMID- 22875402
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20181201
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 4
IP  - 18
DP  - 2012 Sep 21
TI  - Therapeutic application of injectable thermosensitive hydrogel in preventing 
      local breast cancer recurrence and improving incision wound healing in a mouse 
      model.
PG  - 5686-93
LID - 10.1039/c2nr30731f [doi]
AB  - Many drug delivery systems (DDSs) have been investigated for local targeting of 
      malignant disease with the intention of increasing anti-tumor activity and 
      minimizing systemic toxicity. An injectable thermosensitive hydrogel was applied 
      to prevent locoregional recurrence of 4T1 breast cancer in a mouse model. The 
      presented hydrogel, which is based on 
      poly(ethyleneglycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, 
      PECE), flows freely at normal temperature, forms a gel within seconds in situ at 
      body temperature, and eventually releases the drug in a consistent and sustained 
      fashion as it gradually biodegrades. Locoregional recurrence after primary tumor 
      removal was significantly inhibited in mice treated with the paclitaxel 
      (PTX)-loaded PECE hydrogel subcutaneously (9.1%) administered, compared with the 
      blank hydrogel (80.0%), systemic (77.8%) and locally (75.0%) administered PTX, 
      and the control group (100%) (P < 0.01). In addition, tensile strength 
      measurements of the surgical incisions showed that the PECE hydrogel accelerates 
      wound healing at postoperative day 7 (P < 0.05), and days 4 and 14 (P > 0.05), in 
      agreement with histopathological examinations. This novel DDSs represents a 
      promising approach for local adjuvant therapy in malignant disease.
FAU - Lei, Na
AU  - Lei N
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West 
      China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Gong, ChangYang
AU  - Gong C
FAU - Qian, ZhiYong
AU  - Qian Z
FAU - Luo, Feng
AU  - Luo F
FAU - Wang, Cheng
AU  - Wang C
FAU - Wang, HeLan
AU  - Wang H
FAU - Wei, YuQuan
AU  - Wei Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 0 (poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol))
RN  - 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/drug therapy/mortality/pathology
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - Drug Carriers/*chemistry
MH  - Female
MH  - Hydrogel, Polyethylene Glycol Dimethacrylate/*chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Paclitaxel/administration & dosage
MH  - Polyesters/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Secondary Prevention
MH  - Temperature
MH  - Transplantation, Homologous
MH  - Wound Healing
EDAT- 2012/08/10 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - 10.1039/c2nr30731f [doi]
PST - ppublish
SO  - Nanoscale. 2012 Sep 21;4(18):5686-93. doi: 10.1039/c2nr30731f. Epub 2012 Aug 9.