PMID- 22875512
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20120809
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Aug
TI  - [A Bw12 blood type caused by 278C>T mutation of ABO gene].
PG  - 482-4
LID - 10.3760/cma.j.issn.1003-9406.2012.04.023 [doi]
AB  - OBJECTIVE: To determine the serotype and genotype of a sample with ABO blood 
      group discrepancies. METHODS: Serotype was determined with serological method. 
      Sequence specific primer polymerase chain reaction (SSP-PCR) was carried out 
      based on the serotype. Sequences of exons 6 and 7 of ABO gene was analyzed by 
      sequence-based testing (SBT). RESULTS: Completely agglutinated A antigen, half 
      agglutinated B antigen and weak agglutinated anti-B antibody were detected in 
      both erythrocytes and serum, which suggested presence of a ABw serotype. An 
      A/Bw12 genotype was revealed by B subgroup detection. Sequences of exons 6 and 7 
      were 278CT, 297GA and 467CT, 526CG, 657CT, 703GA, 796CA, 803GC, 930GA, 
      respectively. The genotype fit with A102/B101 except for a nt278 C>T mutation. 
      Blood group antigen gene mutation database (BGMUT) search has confirmed the 
      mutant allele to be Bw12. CONCLUSION: An A102/Bw12 genotype has been found in the 
      Chinese population.
FAU - Meng, Qing-li
AU  - Meng QL
AD  - Dalian Blood Center, Dalian, Liaoning, People's Republic of China. 
      mengqingli@dl.cn
FAU - Gao, Yong
AU  - Gao Y
FAU - Chen, Mei
AU  - Chen M
FAU - Duan, Ying
AU  - Duan Y
FAU - Pan, Ling-zi
AU  - Pan LZ
FAU - Yu, Wei-jian
AU  - Yu WJ
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Blood Group Antigens)
SB  - IM
MH  - ABO Blood-Group System/*genetics
MH  - Base Sequence
MH  - Blood Group Antigens/*genetics
MH  - Blood Grouping and Crossmatching/methods
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - *Mutation
EDAT- 2012/08/10 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 940629111 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2012.04.023 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Aug;29(4):482-4. doi: 
      10.3760/cma.j.issn.1003-9406.2012.04.023.