PMID- 22876455
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20191027
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 32
IP  - 2
DP  - 2012 Jun
TI  - Effects of Wenxiao II decoction on the expression of MCP-1 and VCAM-1 in 
      atherosclerotic rabbits.
PG  - 267-72
AB  - OBJECTIVE: To observe the effects of different doses of wenxiao II decoction on 
      the expression of monocyte chemoattractant protein-1 (MCP-1) and vascular cell 
      adhesion molecule-1 (VCAM-1) in an experimental model of atherosclerosis in 
      rabbits and to explore the mechanism by which it alleviates atherosclerosis. 
      METHODS: Sixty 3-4 month-old New Zealand rabbits of both sexes were randomly 
      divided into six groups: simvastain; model; blank; and high-dose, mid-dose, and 
      low-dose wenxiao II decoction groups. Except for those in the blank group, all 
      rabbits were fed a high-cholesterol diet. Carotid atherosclerosis was established 
      by balloon-induced injury to the endothelium of the carotid artery in conjunction 
      with consumption of a high-cholesterol diet. After 8 weeks, all rabbits were 
      killed to evaluate the expression of MCP-1 and VCAM-1 by immunohistochemical 
      staining. RESULTS: Expressions of MCP-1 and VCAM-1 were significantly decreased 
      in all groups except the blank group compared with the model group (P < 0.05). 
      When compared with the simvastain group only variation of MCP-1 expression in 
      low-dose group was not appreciable, and the differences were indistinct (P < 
      0.05). When comparing among wenxiao II decoction groups, MCP-1 expression in the 
      mid- and high-dose groups was significantly lower than that seen in the low-dose 
      group (P< 0.01), but there were no differences among three dosage groups with 
      respect to VCAM-1 expression (P > 0.05). CONCLUSION: These data suggested that 
      high, mid, and low doses of Wenxiao II Decoction can inhibit the expression of 
      MCP-1 and VCAM-1, which may prevent the formation of or stabilize atherosclerotic 
      plaques. There may be a direct relationship between the dosage of wenxiao II 
      decoction and its therapeutic efficacy.
FAU - Huo, Qing-ping
AU  - Huo QP
AD  - Department of Traditional Chinese Medicine, Sixth People's Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai 200233, China. huoqingping005@yahoo.com.cn
FAU - Liu, Han-yan
AU  - Liu HY
FAU - Wang, Yu-xin
AU  - Wang YX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (Chemokine CCL2)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Animals
MH  - Carotid Artery Diseases/*drug therapy/metabolism
MH  - Chemokine CCL2/*analysis
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Qi
MH  - Rabbits
MH  - Simvastatin/therapeutic use
MH  - Vascular Cell Adhesion Molecule-1/*analysis
EDAT- 2012/08/11 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.1016/s0254-6272(13)60023-0 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2012 Jun;32(2):267-72. doi: 10.1016/s0254-6272(13)60023-0.