PMID- 22878150
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20191210
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 181
IP  - 2
DP  - 2013 May
TI  - Prognostic implications of human leukocyte antigen class I expression in patients 
      who underwent surgical resection for non-small-cell lung cancer.
PG  - e57-63
LID - S0022-4804(12)00669-5 [pii]
LID - 10.1016/j.jss.2012.07.029 [doi]
AB  - BACKGROUND: The purpose of the present study was to clarify the prognostic 
      significance of human leukocyte antigen (HLA) class I expression in patients with 
      non-small-cell lung cancer who underwent complete surgical resection. PATIENTS 
      AND METHODS: The expression of HLA class I molecules was evaluated in 403 
      resected NSCLC specimens using immunohistochemistry. The results were scored as 
      the percentage of stained tumor cells and were categorized into three groups: 
      0%-24% (decreased), 25%-79% (heterogeneous), and 80% or more (normal). RESULTS: 
      The expression of HLA class I was evaluated in 124 tumors in the normal 
      expression group, 181 tumors in the heterogeneous expression group, and 98 tumors 
      in the decreased expression group. The 5-year survival rate of all patients after 
      surgery according to the HLA class I expression in the normal, heterogeneous, and 
      decreased groups was 76.6%, 65.9%, and 76.1%, respectively. The prognosis was 
      significantly better in the normal expression group than in the heterogeneous 
      group. Normal HLA class I expression also correlated with favorable survival in 
      patients with stage I disease. CONCLUSIONS: The normal expression of HLA class I 
      was associated with a favorable prognosis compared with the heterogeneous 
      expression group, but no significant difference was observed between the normal 
      expression and decreased expression groups.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Hanagiri, Takeshi
AU  - Hanagiri T
AD  - Second Department of Surgery, University of Occupational and Environmental 
      Health, Kitakyushu, Japan. hanagiri@med.uoeh-u.ac.jp
FAU - Shigematsu, Yoshiki
AU  - Shigematsu Y
FAU - Kuroda, Koji
AU  - Kuroda K
FAU - Baba, Tetsuro
AU  - Baba T
FAU - Shiota, Hironobu
AU  - Shiota H
FAU - Ichiki, Yoshinobu
AU  - Ichiki Y
FAU - Nagata, Yoshika
AU  - Nagata Y
FAU - Yasuda, Manabu
AU  - Yasuda M
FAU - Uramoto, Hidetaka
AU  - Uramoto H
FAU - So, Tomoko
AU  - So T
FAU - Takenoyama, Mitsuhiro
AU  - Takenoyama M
FAU - Tanaka, Fumihiro
AU  - Tanaka F
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120731
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adenocarcinoma/metabolism/mortality/*surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Non-Small-Cell Lung/metabolism/mortality/*surgery
MH  - Carcinoma, Squamous Cell/metabolism/mortality/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - HLA Antigens/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/metabolism/mortality/*surgery
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2012/08/11 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - S0022-4804(12)00669-5 [pii]
AID - 10.1016/j.jss.2012.07.029 [doi]
PST - ppublish
SO  - J Surg Res. 2013 May;181(2):e57-63. doi: 10.1016/j.jss.2012.07.029. Epub 2012 Jul 
      31.