PMID- 22879996
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 8
DP  - 2012
TI  - Perfluorinated compounds in umbilical cord blood and adverse birth outcomes.
PG  - e42474
LID - 10.1371/journal.pone.0042474 [doi]
LID - e42474
AB  - BACKGROUND: Previous animal studies have shown that perfluorinated compounds 
      (PFCs) have adverse impacts on birth outcomes, but the results have been 
      inconclusive in humans. We investigated associations between prenatal exposure to 
      perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic 
      acid (PFNA), and perfluoroundecanoic acid (PFUA) and birth outcomes. METHODS: In 
      total, 429 mother-infant pairs were recruited from the Taiwan Birth Panel Study 
      (TBPS). Demographic data were obtained by interviewing mothers using a structured 
      questionnaire and birth outcomes were extracted from medical records. Cord blood 
      was collected for PFOA, PFOS, PFNA, and PFUA analysis by ultra-high-performance 
      liquid chromatography/tandem mass spectrometry. RESULTS: The geometric mean 
      (standard deviation) levels of PFOA, PFOS, PFNA, and PFUA in cord blood plasma 
      were 1.84 (2.23), 5.94 (1.95), 2.36(4.74), and 10.26 (3.07) ng/mL, respectively. 
      Only PFOS levels were found to be inversely associated with gestational age, 
      birth weight, and head circumference [per ln unit: adjusted beta (95% confidence 
      interval, CI) = -0.37 (-0.60, -0.13) wks, -110.2 (-176.0, -44.5) gm and -0.25 
      (-0.46, -0.05) cm]. Additionally, the odds ratio of preterm birth, low birth 
      weight, and small for gestational age increased with PFOS exposure [per ln unit: 
      adjusted odds ratio (OR) (95%CI) = 2.45 (1.47, 4.08), 2.61(0.85, 8.03) and 2.27 
      (1.25, 4.15)]. When PFOS levels were divided into quartiles, a dose-response 
      relation was observed. However, PFOA, PFNA, and PFUA were not observed to have 
      any convincing impact on birth outcomes. CONCLUSIONS: An adverse dose-dependent 
      association was observed between prenatal PFOS exposure and birth outcomes. 
      However, no associations were found for the other examined PFCs.
FAU - Chen, Mei-Huei
AU  - Chen MH
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Ha, Eun-Hee
AU  - Ha EH
FAU - Wen, Ting-Wen
AU  - Wen TW
FAU - Su, Yi-Ning
AU  - Su YN
FAU - Lien, Guang-Wen
AU  - Lien GW
FAU - Chen, Chia-Yang
AU  - Chen CY
FAU - Chen, Pau-Chung
AU  - Chen PC
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Fluorocarbons)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/blood
MH  - Confidence Intervals
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Odds Ratio
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Regression Analysis
MH  - Taiwan
PMC - PMC3411780
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/08/11 06:00
MHDA- 2013/01/11 06:00
PMCR- 2012/08/03
CRDT- 2012/08/11 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PHST- 2012/08/03 00:00 [pmc-release]
AID - PONE-D-12-12787 [pii]
AID - 10.1371/journal.pone.0042474 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(8):e42474. doi: 10.1371/journal.pone.0042474. Epub 2012 Aug 3.