PMID- 22880108
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 8
DP  - 2012
TI  - The effect of exercise training modality on serum brain derived neurotrophic 
      factor levels in individuals with type 2 diabetes.
PG  - e42785
LID - 10.1371/journal.pone.0042785 [doi]
LID - e42785
AB  - INTRODUCTION: Brain derived neurotrophic factor (BDNF) has been implicated in 
      memory, learning, and neurodegenerative diseases. However, the relationship of 
      BDNF with cardiometabolic risk factors is unclear, and the effect of exercise 
      training on BDNF has not been previously explored in individuals with type 2 
      diabetes. METHODS: Men and women (N = 150) with type 2 diabetes were randomized 
      to an aerobic exercise (aerobic), resistance exercise (resistance), or a 
      combination of both (combination) for 9 months. Serum BDNF levels were evaluated 
      at baseline and follow-up from archived blood samples. RESULTS: Baseline serum 
      BDNF was not associated with fitness, body composition, anthropometry, glucose 
      control, or strength measures (all, p>0.05). Similarly, no significant change in 
      serum BDNF levels was observed following exercise training in the aerobic 
      (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 
      588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to 
      the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in 
      waist circumference were directly associated with changes in serum BDNF following 
      training (r = 0.25, p = 0.005). CONCLUSIONS: Serum BDNF was not associated with 
      fitness, body composition, anthropometry, glucose control, or strength measures 
      at baseline. Likewise, serum BDNF measures were not altered by 9 months of 
      aerobic, resistance, or combination training. However, reductions in waist 
      circumference were associated with decreased serum BDNF levels. Future studies 
      should investigate the relevance of BDNF with measures of cognitive function 
      specifically in individuals with type-2 diabetes.
FAU - Swift, Damon L
AU  - Swift DL
AD  - Department of Preventive Medicine, Pennington Biomedical Research Center, Baton 
      Rouge, Louisiana, United States of America.
FAU - Johannsen, Neil M
AU  - Johannsen NM
FAU - Myers, Valerie H
AU  - Myers VH
FAU - Earnest, Conrad P
AU  - Earnest CP
FAU - Smits, Jasper A J
AU  - Smits JA
FAU - Blair, Steven N
AU  - Blair SN
FAU - Church, Timothy S
AU  - Church TS
LA  - eng
SI  - ClinicalTrials.gov/NCT00458133
GR  - R01 DK068298/DK/NIDDK NIH HHS/United States
GR  - T32 DK064584/DK/NIDDK NIH HHS/United States
GR  - T32 DK 64584-9/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120806
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cardiovascular Diseases/blood/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*physiopathology
MH  - *Exercise
MH  - *Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Statistics, Nonparametric
PMC - PMC3412800
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/08/11 06:00
MHDA- 2013/01/11 06:00
PMCR- 2012/08/06
CRDT- 2012/08/11 06:00
PHST- 2012/03/21 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PHST- 2012/08/06 00:00 [pmc-release]
AID - PONE-D-12-08634 [pii]
AID - 10.1371/journal.pone.0042785 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(8):e42785. doi: 10.1371/journal.pone.0042785. Epub 2012 Aug 6.