PMID- 22881057
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20120813
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 3
DP  - 2012 Sep
TI  - Old and new HLA associations with ankylosing spondylitis.
PG  - 205-13
LID - 10.1111/j.1399-0039.2012.01944.x [doi]
AB  - Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that 
      primarily involves the axial skeleton and the sacroiliac joint, but may also 
      affect peripheral joints and entheses. AS susceptibility is clearly attributable 
      to genetic factors and the link between human leukocyte antigen (HLA)-B27 and AS 
      is the strongest association between an HLA class I molecule and a disease. 
      However, there is evidence for the involvement of other, non-B27 factors within 
      the major histocompatibility complex (MHC) in AS susceptibility. MHC class I is 
      clearly the most significant genetic region for the disease, although most of the 
      genetic association of this region is driven by HLA-B27. Moreover, several 
      studies have investigated the MHC class II region and its association with AS. 
      This review summarizes the current findings concerning the MHC genetics of the 
      disease, focusing in particular on the associations of HLA with AS found in 
      different ethnic populations throughout the world, and the possible mechanisms 
      underlying them.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Diaz-Pena, R
AU  - Diaz-Pena R
AD  - Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, 
      Spain.
FAU - Lopez-Vazquez, A
AU  - Lopez-Vazquez A
FAU - Lopez-Larrea, C
AU  - Lopez-Larrea C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Spondylitis, Ankylosing/*genetics/*immunology
EDAT- 2012/08/14 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.1111/j.1399-0039.2012.01944.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Sep;80(3):205-13. doi: 10.1111/j.1399-0039.2012.01944.x.