PMID- 22881719
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20131121
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 84
IP  - 17
DP  - 2012 Sep 4
TI  - Quantitative real-time monitoring of chemical reactions by autosampling flow 
      injection analysis coupled with atmospheric pressure chemical ionization mass 
      spectrometry.
PG  - 7547-54
LID - 10.1021/ac3017136 [doi]
AB  - Although qualitative and/or semiquantitative real-time monitoring of chemical 
      reactions have been reported with a few mass spectrometric approaches, to our 
      knowledge, no quantitative mass spectrometric approach has been reported so far 
      to have a calibration valid up to molar concentrations as required by process 
      control. This is mostly due to the absence of a practical solution that could 
      well address the sample overloading issue. In this study, a novel autosampling 
      flow injection analysis coupled with an atmospheric pressure chemical ionization 
      mass spectrometry (FIA/APCI-MS) system, consisting of a 1 muL automatic internal 
      sample injector, a postinjection splitter with 1:10 splitting ratio, and a 
      detached APCI source connected to the mass spectrometer using a 4.5 in. long, 
      0.042 in. inner diameter (ID) stainless-steel capillary, was thus introduced. 
      Using this system together with an optional FIA solvent modifier, e.g., 0.05% 
      (v/v) isopropylamine, a linear quantitative calibration up to molar concentration 
      has been achieved with 3.4-7.2% relative standard deviations (RSDs) for 4 
      replicates. As a result, quantitative real-time monitoring of a model reaction 
      was successfully performed at the 1.63 M level. It is expected that this novel 
      autosampling FIA/APCI-MS system can be used in quantitative real-time monitoring 
      of a wide range of reactions under diverse reaction conditions.
FAU - Zhu, Zhenqian
AU  - Zhu Z
AD  - Mass Spectrometry Center, Department of Chemistry, University of Tennessee, 
      Knoxville, Tennessee 37996-1600, United States.
FAU - Bartmess, John E
AU  - Bartmess JE
FAU - McNally, Mary Ellen
AU  - McNally ME
FAU - Hoffman, Ron M
AU  - Hoffman RM
FAU - Cook, Kelsey D
AU  - Cook KD
FAU - Song, Liguo
AU  - Song L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120821
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Phenethylamines)
RN  - 0 (Propylamines)
RN  - 0 (Solvents)
RN  - 327C7L2BXQ (phenethylamine)
RN  - MP1U0D42PE (Acrylonitrile)
RN  - P8W26T4MTD (2-propylamine)
SB  - IM
MH  - Acrylonitrile/chemistry
MH  - Atmospheric Pressure
MH  - Automation
MH  - Calibration
MH  - Flow Injection Analysis
MH  - Phenethylamines/analysis
MH  - Propylamines/chemistry
MH  - Solvents/chemistry
MH  - Spectrometry, Mass, Electrospray Ionization/instrumentation/*methods/standards
EDAT- 2012/08/14 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - 10.1021/ac3017136 [doi]
PST - ppublish
SO  - Anal Chem. 2012 Sep 4;84(17):7547-54. doi: 10.1021/ac3017136. Epub 2012 Aug 21.