PMID- 22883353
OWN - NLM
STAT- MEDLINE
DCOM- 20130813
LR  - 20221207
IS  - 1092-8529 (Print)
IS  - 1092-8529 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Sep
TI  - Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met 
      polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in 
      Japanese patients with major depressive disorder (MDD).
PG  - 155-63
LID - 10.1017/S109285291200051X [doi]
AB  - OBJECT: We investigated an association between the polymorphism of brain-derived 
      neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in 
      Japanese patients with major depressive disorder (MDD). We also examined 
      mirtazapine's effects on the serum BDNF and plasma levels of catecholamine 
      metabolites in these patients. METHODS: Eighty-four patients who met the 
      DSM-IV-TR criteria for MDD were treated with only mirtazapine for 4 weeks. The 
      BDNF Val66Met polymorphism was detected by direct sequencing in the region, and 
      serum BDNF levels and plasma levels of catecholamine metabolites were measured by 
      ELISA and HPLC-ECD, respectively. RESULTS: Mirtazapine treatment for 4 weeks 
      significantly increased serum BDNF levels in the responders, whereas 
      nonresponders showed significant decreases. No association was found between 
      either of the two genotypes (Val/Val vs. Met-carriers) and the response to 
      mirtazapine at T4 or the serum BDNF levels at T0. Mirtazapine did not alter the 
      plasma levels of homovanillic acid (HVA) or 3-methoxy-4-hydroxyphenylglycol 
      (MHPG). Discussion The dynamics of serum BDNF levels, but not plasma levels of 
      HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met 
      polymorphism in patients with depression is, however, associated with neither a 
      particular response to mirtazapine treatment nor baseline serum BDNF levels. 
      CONCLUSION: Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF 
      Val66Met polymorphism are related to the mirtazapine response in MDD.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
FAU - Kishi, Taro
AU  - Kishi T
FAU - Hori, Hikaru
AU  - Hori H
FAU - Umene-Nakano, Wakako
AU  - Umene-Nakano W
FAU - Ikenouchi-Sugita, Atsuko
AU  - Ikenouchi-Sugita A
FAU - Hayashi, Kenji
AU  - Hayashi K
FAU - Atake, Kiyokazu
AU  - Atake K
FAU - Iwata, Nakao
AU  - Iwata N
FAU - Nakamura, Jun
AU  - Nakamura J
LA  - eng
PT  - Journal Article
DEP - 20120810
PL  - United States
TA  - CNS Spectr
JT  - CNS spectrums
JID - 9702877
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catecholamines)
RN  - 0 (Ethylene Glycols)
RN  - 0 (Phenols)
RN  - 2380-75-8 (4-hydroxyphenethylene glycol)
RN  - 250PJI13LM (Mianserin)
RN  - A051Q2099Q (Mirtazapine)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antidepressive Agents/*therapeutic use
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Catecholamines/*blood
MH  - Chromatography, High Pressure Liquid
MH  - *Depressive Disorder, Major/blood/drug therapy/genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ethylene Glycols
MH  - Female
MH  - Homovanillic Acid/blood
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Mianserin/*analogs & derivatives/therapeutic use
MH  - Middle Aged
MH  - Mirtazapine
MH  - Phenols
MH  - Polymorphism, Genetic/genetics
MH  - Psychiatric Status Rating Scales
MH  - Statistics, Nonparametric
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2012/08/14 06:00
MHDA- 2013/08/14 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/08/14 06:00 [medline]
AID - S109285291200051X [pii]
AID - 10.1017/S109285291200051X [doi]
PST - ppublish
SO  - CNS Spectr. 2012 Sep;17(3):155-63. doi: 10.1017/S109285291200051X. Epub 2012 Aug 
      10.