PMID- 22883481
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20131121
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 321
IP  - 1-2
DP  - 2012 Oct 15
TI  - Oxidative stress in multiple sclerosis patients in clinical remission: 
      association with the expanded disability status scale.
PG  - 49-53
LID - 10.1016/j.jns.2012.07.045 [doi]
AB  - Increased levels of oxidative stress markers and/or decreased levels of 
      antioxidant molecules have been described in patients with multiple sclerosis 
      (MS). This imbalance has been implicated in demyelination and axonal damage. The 
      aims of this study were to evaluate oxidative stress in MS patients and to verify 
      its correlation with disability as assessed by the expanded disability status 
      scale (EDSS). This case-controlled study included 91 patients with 
      relapsing-remitting multiple sclerosis (RR-MS) and 196 healthy individuals 
      matched by age, gender, ethnicity, smoking status, and body mass index. Oxidative 
      stress was evaluated by tert-butyl hydroperoxide-initiated chemiluminescence 
      (CL-LOOH), carbonyl protein, nitric oxide metabolites (NOx), total 
      radical-trapping antioxidant parameter (TRAP), sulfhydryl groups of proteins and 
      serum uric acid levels. MS patients exhibited higher plasma levels of CL-LOOH 
      (p<0.0001) and carbonyl protein (p=0.0081), and lower plasma levels of NOx 
      (p<0.0001), TRAP (p=0.0088), and sulfhydryl groups (p=0.0003) compared to the 
      control subjects. A multivariate analysis showed an association between oxidative 
      markers and the presence of MS. Patients with an EDSS >3.5 showed higher CL-LOOH 
      than control subjects (p=0.0093). A positive correlation was observed between 
      CL-LOOH and EDSS (r=0.3244, p=0.0026) and between carbonyl protein and EDSS 
      (r=0.3012, p=0.0041). These results demonstrate that oxidative stress plays an 
      important role in the physiopathology of MS progression.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Oliveira, Sayonara Rangel
AU  - Oliveira SR
AD  - Postgraduate Program, Health Sciences Center, State University of Londrina, 
      Londrina, Brazil.
FAU - Kallaur, Ana Paula
AU  - Kallaur AP
FAU - Simao, Andrea Name Colado
AU  - Simao AN
FAU - Morimoto, Helena Kaminami
AU  - Morimoto HK
FAU - Lopes, Josiane
AU  - Lopes J
FAU - Panis, Carolina
AU  - Panis C
FAU - Petenucci, Diego Lima
AU  - Petenucci DL
FAU - da Silva, Eloisa
AU  - da Silva E
FAU - Cecchini, Rubens
AU  - Cecchini R
FAU - Kaimen-Maciel, Damacio Ramon
AU  - Kaimen-Maciel DR
FAU - Reiche, Edna Maria Vissoci
AU  - Reiche EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Mediator Complex)
RN  - 268B43MJ25 (Uric Acid)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Disability Evaluation
MH  - *Disabled Persons
MH  - Female
MH  - Humans
MH  - Luminescence
MH  - Male
MH  - Mediator Complex/metabolism
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*metabolism/*physiopathology
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress/*physiology
MH  - Protein Carbonylation/physiology
MH  - Statistics, Nonparametric
MH  - Uric Acid/metabolism
EDAT- 2012/08/14 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/03/17 00:00 [received]
PHST- 2012/05/26 00:00 [revised]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - S0022-510X(12)00399-1 [pii]
AID - 10.1016/j.jns.2012.07.045 [doi]
PST - ppublish
SO  - J Neurol Sci. 2012 Oct 15;321(1-2):49-53. doi: 10.1016/j.jns.2012.07.045. Epub 
      2012 Aug 9.