PMID- 22883583
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20190221
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 47
IP  - 5
DP  - 2012 May
TI  - [Role of vasculogenic mimicry and endothelium-dependent vessel in metastasis of 
      laryngeal cancer].
PG  - 400-5
AB  - OBJECTIVE: To investigate the contribution of vasculogenic mimicry (VM) and 
      endothelium-dependent vessel (EDV) to invasion and metastasis of laryngeal 
      squamous cell carcinoma (LSCC). METHODS: A total of 203 cases with LSCC was 
      reviewed and followed up. VM and EDV in LSCC tissues were assessed by double 
      staining with anti-CD31 immunohistochemistry and periodic acid-schiff. 
      Kruskal-Wallis test and one-way ANOVA were used to analyze the relationship 
      between VM, EDV and clinical pathology parameters of LSCC. Kaplan-Meier analysis 
      was used to evaluate overall survival (OS) of patients with LSCC. RESULTS: VM 
      related to pTNM stage, lymph node metastasis and pathology grade of LSCC, while 
      EDV related to primary sites, pTNM stage, T stage and distant metastasis of LSCC. 
      Univariate analysis showed VM (P = 0.014), pTNM stage (P = 0.009), T stage (P = 
      0.013), nodal status (P = 0.013), histopathology grade (P = 0.038), tumor size (P 
      = 0.028), and radiotherapy (P < 0.0001) related to OS. VM (P = 0.011), primary 
      sites (P = 0.049), tumor size (P = 0.001) and radiotherapy (P < 0.0001) related 
      to disease free survival. Multivariate analysis indicated that VM was an adverse 
      predictor for both OS and disease free survival. CONCLUSIONS: Both VM and EDV 
      existed in LSCC. VM contributed to progression of LSCC through promoting lymph 
      node metastasis. VM is an independent predictor for the prognosis of LSCC.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central 
      Hospital, Tianjin Otorhinolaryngology Institution, the First Clinical Department 
      of Tianjin Medical University, Tianjin 300384, China.
FAU - Lin, Peng
AU  - Lin P
FAU - Sun, Bao-cun
AU  - Sun BC
FAU - Cai, Wen-juan
AU  - Cai WJ
FAU - Han, Chun-rong
AU  - Han CR
FAU - Li, Li
AU  - Li L
FAU - Lu, Hong-hua
AU  - Lu HH
FAU - Zhang, Jin-mei
AU  - Zhang JM
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*blood supply/diagnosis/pathology
MH  - Endothelium, Vascular
MH  - Female
MH  - Head and Neck Neoplasms/*blood supply/diagnosis/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*blood supply/diagnosis/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2012/08/14 06:00
MHDA- 2015/04/18 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;47(5):400-5.