PMID- 22884005
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121001
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 93
IP  - 3
DP  - 2012 Dec
TI  - Infectious risk factors for individual postweaning multisystemic wasting syndrome 
      (PMWS) development in pigs from affected farms in Spain and Denmark.
PG  - 1231-40
LID - S0034-5288(12)00209-3 [pii]
LID - 10.1016/j.rvsc.2012.07.001 [doi]
AB  - Two prospective longitudinal studies in 13 postweaning multisystemic wasting 
      syndrome (PMWS)-affected farms from Spain (n=3) and Denmark (n=10) were 
      performed. Blood samples from pigs were longitudinally collected from 1st week 
      until the occurrence of the PMWS outbreak. Wasted and healthy age-matched pigs 
      were euthanized, necropsied and histopathologically characterised. PMWS diagnosis 
      was confirmed by means of lymphoid lesions and detection of porcine circovirus 
      type 2 (PCV2) in these tissues by in situ hybridization or immunohistochemistry. 
      Serological analyses were performed in longitudinally collected serum samples to 
      detect antibodies against, PCV2, porcine reproductive and respiratory syndrome 
      virus (PRRSV), porcine parvovirus (PPV), swine influenza virus (SIV) and Lawsonia 
      intracellularis (law), Mycoplasma hyopneumoniae, Aujeszky's disease virus (ADV) 
      and Salmonella spp. A Cox proportional hazards model was used to investigate the 
      simultaneous effects of seroconversion and maternal immunity against the studied 
      pathogens. Results showed that high levels of maternal immunity against PCV2 had 
      a protecting effect in farms from both countries. Moreover, for the Danish 
      dataset, seroconversion against law had an overall protecting effect, but for 
      animals with very low levels of maternal antibody levels against this pathogen, 
      the effect appeared neutral or aggravating. Otherwise, for the Spanish dataset, 
      maternal immunity against PPV and PRRSV gave protective and aggravating effects, 
      respectively. In conclusion, the present study reflects the complex interaction 
      among different pathogens and their effects in order to trigger PMWS in PCV2 
      infected pigs.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Grau-Roma, Llorenc
AU  - Grau-Roma L
AD  - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 
      08193 Bellaterra, Barcelona, Spain. llorenc.grau@uab.cat
FAU - Stockmarr, Anders
AU  - Stockmarr A
FAU - Kristensen, Charlotte S
AU  - Kristensen CS
FAU - Enoe, Claes
AU  - Enoe C
FAU - Lopez-Soria, Sergio
AU  - Lopez-Soria S
FAU - Nofrarias, Miquel
AU  - Nofrarias M
FAU - Bille-Hansen, Vivi
AU  - Bille-Hansen V
FAU - Hjulsager, Charlotte K
AU  - Hjulsager CK
FAU - Sibila, Marina
AU  - Sibila M
FAU - Jorsal, Sven E
AU  - Jorsal SE
FAU - Fraile, Lorenzo
AU  - Fraile L
FAU - Baekbo, Poul
AU  - Baekbo P
FAU - Vigre, Hakan
AU  - Vigre H
FAU - Segales, Joaquim
AU  - Segales J
FAU - Larsen, Lars E
AU  - Larsen LE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
SB  - IM
MH  - Animals
MH  - Denmark/epidemiology
MH  - Female
MH  - Immunity, Maternally-Acquired
MH  - Porcine Postweaning Multisystemic Wasting Syndrome/epidemiology/*microbiology
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Spain/epidemiology
MH  - Swine
EDAT- 2012/08/14 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/08/14 06:00
PHST- 2011/09/19 00:00 [received]
PHST- 2012/06/28 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - S0034-5288(12)00209-3 [pii]
AID - 10.1016/j.rvsc.2012.07.001 [doi]
PST - ppublish
SO  - Res Vet Sci. 2012 Dec;93(3):1231-40. doi: 10.1016/j.rvsc.2012.07.001. Epub 2012 
      Aug 9.