PMID- 22884083
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20171116
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 11
DP  - 2012 Jun
TI  - JAK2 V617F positive essential thrombocythemia developing in a patient with CD5(-) 
      chronic lymphocytic leukemia.
PG  - 2076-9
AB  - Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia 
      (ET) in a patient is extremely rare, with only 10 cases reported thus far in 
      literature. This paper describes a 94-year-old male having atypical B-CLL with 
      CD5(-) (CD5(-)) phenotype and ET. In this patient, we performed interphase 
      fluorescence in situ hybridization (FISH) analysis which revealed 13q14.3 
      deletion in 31% of B-lymphocyte nuclei and RB1 deletion in 27% of B-lymphocyte 
      nuclei, but not in neutrophils and T-lymphocytes. Furthermore, we identified JAK2 
      V617F mutation in the peripheral blood nucleated cells and neutrophils, but not 
      in the B- and T-lymphocyte populations. Therefore, it was concluded that the 
      occurrence of CD5- B-CLL and ET in this patient was pathogenically independent.
FAU - Wei, Ju
AU  - Wei J
AD  - Department of Hematology, Shanghai First People's Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200080, China. weiju@medmail.com.cn
FAU - Wang, Chun
AU  - Wang C
FAU - Qin, You-Wen
AU  - Qin YW
FAU - Zhu, Jun
AU  - Zhu J
FAU - Gao, Yang-Rong
AU  - Gao YR
FAU - Cai, Qi
AU  - Cai Q
FAU - Yan, Shi-Ke
AU  - Yan SK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (CD5 Antigens)
RN  - EC 2.7.10.2 (Janus Kinase 2)
SB  - IM
MH  - Aged, 80 and over
MH  - CD5 Antigens/*metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - Janus Kinase 2/*genetics
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/metabolism
MH  - Male
MH  - Mutation
MH  - Thrombocythemia, Essential/*genetics/metabolism
EDAT- 2012/08/14 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Jun;125(11):2076-9.