PMID- 22884298
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20221207
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 251
IP  - 1-2
DP  - 2012 Oct 15
TI  - HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese.
PG  - 110-3
LID - 10.1016/j.jneuroim.2012.07.007 [doi]
AB  - To determine the relationship between susceptibility to atopic myelitis (AM) and 
      polymorphisms of the human leukocyte antigen (HLA)-DPB1 and -DRB1 alleles, we 
      compared each phenotype frequency between 55 AM patients and 367 unrelated 
      healthy controls in Japan. The HLA-DPB1*0201 allele was significantly more 
      frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P 
      value=0.0150, odds ratio=2.564, 95% confidence interval=1.444-4.554). Our result 
      suggests that the immunogenetic background of AM differs from that of other CNS 
      autoimmune diseases, such as multiple sclerosis and neuromyelitis optica, which 
      show distinct HLA class II associations.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Sato, Shinya
AU  - Sato S
AD  - Department of Neurology, Neurological Institute, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka, Japan.
FAU - Isobe, Noriko
AU  - Isobe N
FAU - Yoshimura, Satoshi
AU  - Yoshimura S
FAU - Kanamori, Yuji
AU  - Kanamori Y
FAU - Masaki, Katsuhisa
AU  - Masaki K
FAU - Matsushita, Takuya
AU  - Matsushita T
FAU - Kira, Jun-Ichi
AU  - Kira J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1*02:01 antigen)
SB  - IM
MH  - Asian People/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DP beta-Chains/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/genetics/immunology
MH  - Myelitis/*genetics/immunology
MH  - Neuromyelitis Optica/genetics/immunology
MH  - Polymorphism, Genetic
EDAT- 2012/08/14 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/06/04 00:00 [revised]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0165-5728(12)00219-6 [pii]
AID - 10.1016/j.jneuroim.2012.07.007 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2012 Oct 15;251(1-2):110-3. doi: 10.1016/j.jneuroim.2012.07.007. 
      Epub 2012 Aug 9.