PMID- 22884556
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20121001
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Nov
TI  - Recurrent pericarditis: autoimmune or autoinflammatory?
PG  - 60-5
LID - S1568-9972(12)00159-0 [pii]
LID - 10.1016/j.autrev.2012.07.023 [doi]
AB  - Idiopathic recurrent acute pericarditis (IRAP) represents the most troublesome 
      complication of acute pericarditis and occurs in up to 20-50% of patients. It is 
      generally idiopathic or postcardiac injury. IRAP is a disease of suspected 
      immune-mediated pathogenesis. On the other hand, it has been suggested that some 
      of these patients might have an atypical or subclinical form of an 
      autoinflammatory disease, e.g. genetic disorders characterized by primary 
      dysfunction of the innate immune system and caused by mutations of genes involved 
      in the inflammatory response. We found that IRAP patients were negative for 
      mutations associated with familial Mediterranean fever, but 6% (8/131 patients) 
      carry a mutation in the TNFRSF1A gene, encoding the receptor for tumor necrosis 
      factor-alfa. C-reactive protein (CRP) may be useful to follow the disease 
      activity and guide the appropriate length of therapy, with continuation of the 
      attack doses of the drugs until CRP normalization, at which time tapering may be 
      considered. IRAP often needs a multidrug therapy: NSAIDs or aspirin at high 
      dosages every 6-8h, corticosteroids only rarely, at low dosages and with a very 
      gradual tapering (months) and colchicine at low dosages if tolerated. Anakinra 
      could be a solution for patients who do not tolerate other therapies.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Maestroni, Silvia
AU  - Maestroni S
AD  - Internal Medicine, Ospedali Riuniti, Bergamo, Italy. 
      smaestroni@ospedaliriuniti.bergamo.it
FAU - Di Corato, Paola Rita
AU  - Di Corato PR
FAU - Cumetti, Davide
AU  - Cumetti D
FAU - Chiara, Di Blasi Lo Cuccio
AU  - Chiara DB
FAU - Ghidoni, Silvia
AU  - Ghidoni S
FAU - Prisacaru, Lilia
AU  - Prisacaru L
FAU - Cantarini, Luca
AU  - Cantarini L
FAU - Imazio, Massimo
AU  - Imazio M
FAU - Penco, Silvana
AU  - Penco S
FAU - Pedrotti, Patrizia
AU  - Pedrotti P
FAU - Caforio, Alida L P
AU  - Caforio AL
FAU - Doria, Andrea
AU  - Doria A
FAU - Brucato, Antonio
AU  - Brucato A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120802
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Autoimmune Diseases/genetics/*immunology
MH  - Humans
MH  - Inflammation/genetics/*immunology
MH  - Pericarditis/*drug therapy/genetics/*immunology/pathology
MH  - Recurrence
EDAT- 2012/08/14 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S1568-9972(12)00159-0 [pii]
AID - 10.1016/j.autrev.2012.07.023 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2012 Nov;12(1):60-5. doi: 10.1016/j.autrev.2012.07.023. Epub 2012 
      Aug 2.