PMID- 22885332
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1528-0012 (Electronic)
IS  - 0016-5085 (Print)
IS  - 0016-5085 (Linking)
VI  - 143
IP  - 4
DP  - 2012 Oct
TI  - Effects of bariatric surgery on glucose homeostasis and type 2 diabetes.
PG  - 897-912
LID - S0016-5085(12)01156-0 [pii]
LID - 10.1053/j.gastro.2012.07.114 [doi]
AB  - Obesity is an important risk factor for type 2 diabetes mellitus (T2DM). Weight 
      loss improves the major factors involved in the pathogenesis of T2DM, namely 
      insulin action and beta cell function, and is considered a primary therapy for 
      obese patients who have T2DM. Unfortunately, most patients with T2DM fail to 
      achieve successful weight loss and adequate glycemic control from medical 
      therapy. In contrast, bariatric surgery causes marked weight loss and complete 
      remission of T2DM in most patients. Moreover, bariatric surgical procedures that 
      divert nutrients away from the upper gastrointestinal tract are more successful 
      in producing weight loss and remission of T2DM than those that simply restrict 
      stomach capacity. Although upper gastrointestinal tract bypass procedures alter 
      the metabolic response to meal ingestion, by increasing early postprandial plasma 
      concentrations of glucagon-like peptide 1 and insulin, it is not clear whether 
      these effects make an important contribution to long-term control of glycemia and 
      T2DM once substantial surgery-induced weight loss has occurred. Nonetheless, the 
      effects of surgery on body weight and metabolic function indicate that bariatric 
      surgery should be part of the standard therapy for T2DM. More research is needed 
      to advance our understanding of the physiological effects of different bariatric 
      surgical procedures and possible weight loss-independent factors that improve 
      metabolic function and contribute to the resolution of T2DM.
CI  - Copyright (c) 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Bradley, David
AU  - Bradley D
AD  - Center for Human Nutrition, Washington University School of Medicine, St Louis, 
      Missouri 63110, USA.
FAU - Magkos, Faidon
AU  - Magkos F
FAU - Klein, Samuel
AU  - Klein S
LA  - eng
GR  - DK37948/DK/NIDDK NIH HHS/United States
GR  - T32 HL007456/HL/NHLBI NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - R01 DK037948/DK/NIDDK NIH HHS/United States
GR  - DK56341/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120808
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - *Bariatric Surgery
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*surgery
MH  - *Homeostasis
MH  - Humans
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/metabolism
MH  - Obesity/surgery
PMC - PMC3462491
MID - NIHMS407658
EDAT- 2012/08/14 06:00
MHDA- 2012/12/18 06:00
PMCR- 2013/10/01
CRDT- 2012/08/14 06:00
PHST- 2012/05/05 00:00 [received]
PHST- 2012/07/20 00:00 [revised]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - S0016-5085(12)01156-0 [pii]
AID - 10.1053/j.gastro.2012.07.114 [doi]
PST - ppublish
SO  - Gastroenterology. 2012 Oct;143(4):897-912. doi: 10.1053/j.gastro.2012.07.114. 
      Epub 2012 Aug 8.