PMID- 22886850
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20121030
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 42
IP  - 11
DP  - 2012 Nov
TI  - Specific CD8(+) T cells recognize human herpesvirus 6B.
PG  - 2901-12
LID - 10.1002/eji.201242439 [doi]
AB  - The importance of human herpesvirus 6 (HHV-6) species as human pathogens is 
      increasingly appreciated. However, we do not understand how infection is 
      controlled in healthy virus carriers, and why control fails in patients with 
      disease. Other persistent viruses are under continuous surveillance by 
      antigen-specific T cells, and specific T-cell repertoires have been well 
      characterized for some of them. In contrast, knowledge on HHV-6-specific T-cell 
      responses is limited, and missing for CD8(+) T cells. Here we identify CD8(+) 
      T-cell responses to HHV-6B, the most widespread HHV-6 species, in healthy virus 
      carriers. HHV-6B-specific CD8(+) T-cell lines and clones recognized 
      HLA-A2-restricted peptides from the viral structural proteins U54 and U11, and 
      displayed various antigen-specific antiviral effector functions. These CD8(+) T 
      cells specifically recognized HHV-6B-infected primary CD4(+) T cells in an 
      HLA-restricted manner, produced antiviral cytokines, and killed infected cells, 
      whereas HHV-6A-infected cells were not recognized. Thus, HHV-6B-specific CD8(+) T 
      cells are likely to contribute to control of infection, overcoming the 
      immunomodulatory effects exerted by the virus. Potentially, HHV-6-associated 
      disease could be addressed by active or passive immunotherapy that reconstitutes 
      virus-specific CD8(+) T-cell responses.
CI  - (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Martin, Larissa K
AU  - Martin LK
AD  - Clinical Cooperation Group Immunooncology, Department of Medicine III, Klinikum 
      der Universitat Munchen and Department of Gene Vectors, Helmholtz Zentrum 
      Munchen, Munich, Germany.
FAU - Schub, Andrea
AU  - Schub A
FAU - Dillinger, Stefan
AU  - Dillinger S
FAU - Moosmann, Andreas
AU  - Moosmann A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, Viral)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Antigens, Viral/blood/*immunology
MH  - CD8-Positive T-Lymphocytes/cytology/*immunology/virology
MH  - Carrier State/immunology/virology
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Flow Cytometry
MH  - HLA-A2 Antigen/immunology
MH  - Herpesvirus 6, Human/genetics/*immunology
MH  - Humans
MH  - Leukocytes, Mononuclear/immunology
MH  - Molecular Sequence Data
MH  - RNA, Viral/chemistry/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Roseolovirus Infections/*immunology/virology
MH  - Viral Structural Proteins/immunology
EDAT- 2012/08/14 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/02/05 00:00 [received]
PHST- 2012/06/23 00:00 [revised]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - 10.1002/eji.201242439 [doi]
PST - ppublish
SO  - Eur J Immunol. 2012 Nov;42(11):2901-12. doi: 10.1002/eji.201242439. Epub 2012 Sep 
      26.