PMID- 22888844
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121112
LR  - 20211021
IS  - 1477-5956 (Electronic)
IS  - 1477-5956 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Aug 13
TI  - The orosomucoid 1 protein (alpha1 acid glycoprotein) is overexpressed in odontogenic 
      myxoma.
PG  - 49
LID - 10.1186/1477-5956-10-49 [doi]
AB  - BACKGROUND: Odontogenic myxoma (OM) is a benign, but locally invasive, neoplasm 
      occurring in the jaws. However, the molecules implicated in its development are 
      unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding 
      the enamel organ, is derived from ectomesenchymal/mesencyhmal elements. To 
      identify some protein that could participate in the development of this neoplasm, 
      total proteins from OM were separated by two-dimensional electrophoresis and the 
      profiles were compared with those obtained from DF, used as a control. RESULTS: 
      We identified eight proteins with differential expression; two of them were 
      downregulated and six upregulated in OM. A spot consistently overexpressed in 
      odontogenic myxoma, with a molecular weight of 44-kDa and a pI of 3.5 was 
      identified as the orosomucoid 1 protein. Western blot experiments confirmed the 
      overexpression of this protein in odontogenic myxoma and immunohistochemical 
      assays showed that this protein was mainly located in the cytoplasm of stellate 
      and spindle-shaped cells of this neoplasm. CONCLUSION: Orosomucoid 1, which 
      belongs to a group of acute-phase proteins, may play a role in the modulation of 
      the immune system and possibly it influences the development of OM.
FAU - Garcia-Munoz, Alejandro
AU  - Garcia-Munoz A
AD  - Departamento de Infectomica y Patogenesis Molecular, CINVESTAV-IPN, Mexico, D,F,, 
      Mexico. marodri@cinvestav.mx.
FAU - Rodriguez, Mario A
AU  - Rodriguez MA
FAU - Bologna-Molina, Ronell
AU  - Bologna-Molina R
FAU - Cazares-Raga, Febe E
AU  - Cazares-Raga FE
FAU - Hernandez-Hernandez, Fidel C
AU  - Hernandez-Hernandez FC
FAU - Farfan-Morales, J Eduardo
AU  - Farfan-Morales JE
FAU - Trujillo, Juan J
AU  - Trujillo JJ
FAU - Liceaga-Escalera, Carlos
AU  - Liceaga-Escalera C
FAU - Mendoza-Hernandez, Guillermo
AU  - Mendoza-Hernandez G
LA  - eng
PT  - Journal Article
DEP - 20120813
PL  - England
TA  - Proteome Sci
JT  - Proteome science
JID - 101170539
PMC - PMC3493304
EDAT- 2012/08/15 06:00
MHDA- 2012/08/15 06:01
PMCR- 2012/08/13
CRDT- 2012/08/15 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/08/15 06:01 [medline]
PHST- 2012/08/13 00:00 [pmc-release]
AID - 1477-5956-10-49 [pii]
AID - 10.1186/1477-5956-10-49 [doi]
PST - epublish
SO  - Proteome Sci. 2012 Aug 13;10(1):49. doi: 10.1186/1477-5956-10-49.