PMID- 22889002
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20181202
IS  - 1532-4206 (Electronic)
IS  - 0743-5800 (Linking)
VI  - 38
IP  - 2
DP  - 2013
TI  - The essential role of anti-thyroid antibodies in chronic idiopathic urticaria.
PG  - 85-8
LID - 10.3109/07435800.2012.714432 [doi]
AB  - BACKGROUND: An autoimmune etiology has been suggested in up to one-third of cases 
      of chronic idiopathic urticaria (CIU), in which it has been proposed that a 
      subset of cases are associated with thyroid autoimmunity. The objective of our 
      present study was to verify the prevalence of thyroid antibodies in the patients 
      with CIU. METHODS: Sixty patients aged 12-51 years, who met criteria for CIU, and 
      40 aged-matched healthy controls (18 males and 22 females) were participated in 
      this study. Serum anti-thyroid antibodies (ATAs), thyroid hormones, total 
      immunoglobulin E (IgE), and food allergen-specific IgE antibodies were measured. 
      The CIU group was treated with anti-H1 and anti-H2 histamines for 3 weeks. 
      RESULTS: The total ATA positive rate was 27.3% (33% males and 25% females) in the 
      CIU group. The prevalence of anti-thyroglobulin antibodies, anti-TSH-receptor 
      antibodies, and anti-thyroid peroxidase antibodies were 16.6%, 83.3%, and 8.3%, 
      respectively. The thyroid hormones, T3, and T4, and the TSH were within the 
      normal limits. The radioallergosorbent test was negative for food allergens, and 
      only 18% of the patients had a total IgE concentration >200 IU/mL. CONCLUSION: 
      ATAs were found in 27% of the patients with CIU, but these antibodies did not 
      dysregulate thyroid hormone secretion nor did they mediate any clinical 
      manifestations.
FAU - Wan, Kong-Sang
AU  - Wan KS
AD  - Department of Pediatrics, Taipei City Hospital-Renai Branch, Taipei, Taiwan. 
      gwan1998@gmail.com
FAU - Wu, Chyi-Sen
AU  - Wu CS
LA  - eng
PT  - Journal Article
DEP - 20120813
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 0 (Autoantibodies)
RN  - 0 (Thyroid Hormones)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/biosynthesis/*physiology
MH  - Child
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/physiology
MH  - Male
MH  - Middle Aged
MH  - Thyroid Gland/*immunology/metabolism
MH  - Thyroid Hormones/immunology
MH  - Urticaria/blood/drug therapy/*immunology
MH  - Young Adult
EDAT- 2012/08/15 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.3109/07435800.2012.714432 [doi]
PST - ppublish
SO  - Endocr Res. 2013;38(2):85-8. doi: 10.3109/07435800.2012.714432. Epub 2012 Aug 13.