PMID- 22889373
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20211021
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 9
DP  - 2012 Aug 13
TI  - Increased cellular immune responses and CD4+ T-cell proliferation correlate with 
      reduced plasma viral load in SIV challenged recombinant simian varicella virus - 
      simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques.
PG  - 160
LID - 10.1186/1743-422X-9-160 [doi]
AB  - BACKGROUND: An effective AIDS vaccine remains one of the highest priorities in 
      HIV-research. Our recent study showed that vaccination of rhesus macaques with 
      recombinant simian varicella virus (rSVV) vector - simian immunodeficiency virus 
      (SIV) envelope and gag genes, induced neutralizing antibodies and cellular immune 
      responses to SIV and also significantly reduced plasma viral loads following 
      intravenous pathogenic challenge with SIVMAC251/CX1. FINDINGS: The purpose of 
      this study was to define cellular immunological correlates of protection in 
      rSVV-SIV vaccinated and SIV challenged animals. Immunofluorescent staining and 
      multifunctional assessment of SIV-specific T-cell responses were evaluated in 
      both Experimental and Control vaccinated animal groups. Significant increases in 
      the proliferating CD4+ T-cell population and polyfunctional T-cell responses were 
      observed in all Experimental-vaccinated animals compared with the 
      Control-vaccinated animals. CONCLUSIONS: Increased CD4+ T-cell proliferation was 
      significantly and inversely correlated with plasma viral load. Increased 
      SIV-specific polyfunctional cytokine responses and increased proliferation of 
      CD4+ T-cell may be crucial to control plasma viral loads in vaccinated and 
      SIVMAC251/CX1 challenged macaques.
FAU - Pahar, Bapi
AU  - Pahar B
AD  - Division of Microbiology, Tulane National Primate Research Center, Tulane 
      University School of Medicine, Covington, LA 70433, USA.
FAU - Gray, Wayne L
AU  - Gray WL
FAU - Phelps, Kimberly
AU  - Phelps K
FAU - Didier, Elizabeth S
AU  - Didier ES
FAU - deHaro, Eileen
AU  - deHaro E
FAU - Marx, Preston A
AU  - Marx PA
FAU - Traina-Dorge, Vicki L
AU  - Traina-Dorge VL
LA  - eng
GR  - R01-AI052373/AI/NIAID NIH HHS/United States
GR  - P51 OD011104/OD/NIH HHS/United States
GR  - P20RR016456/RR/NCRR NIH HHS/United States
GR  - AI045510/AI/NIAID NIH HHS/United States
GR  - P51-RR000164-51./RR/NCRR NIH HHS/United States
GR  - R21 AI080395/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120813
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (Cytokines)
RN  - 0 (SAIDS Vaccines)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Proliferation
MH  - Cytokines/metabolism
MH  - Macaca mulatta
MH  - Plasma/virology
MH  - SAIDS Vaccines/administration & dosage/genetics/*immunology
MH  - Simian Immunodeficiency Virus/*genetics/immunology
MH  - Vaccines, Synthetic/administration & dosage/genetics/immunology
MH  - Varicellovirus/*genetics
MH  - *Viral Load
MH  - Viremia/*prevention & control
PMC - PMC3485174
EDAT- 2012/08/15 06:00
MHDA- 2013/04/06 06:00
PMCR- 2012/08/13
CRDT- 2012/08/15 06:00
PHST- 2012/02/14 00:00 [received]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
PHST- 2012/08/13 00:00 [pmc-release]
AID - 1743-422X-9-160 [pii]
AID - 10.1186/1743-422X-9-160 [doi]
PST - epublish
SO  - Virol J. 2012 Aug 13;9:160. doi: 10.1186/1743-422X-9-160.