PMID- 22889406
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20171116
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 10
IP  - 6
DP  - 2012 Dec
TI  - Effect of a low-fat versus a low-gycemic-load diet on inflammatory biomarker and 
      adipokine concentrations.
PG  - 437-42
LID - 10.1089/met.2012.0012 [doi]
AB  - BACKGROUND: Low-grade inflammation is linked to metabolic syndrome and obesity. 
      We studied the effects of weight loss and dietary composition on serum 
      concentrations of biomarkers of inflammation and adipokines. METHODS: Men and 
      women (n=181) aged 30-65 years with a body mass index (BMI) of 28-40 kg/m(2) 
      (28-35 kg/m(2) for women) and one or more components of metabolic syndrome were 
      randomized to follow one of two hypocaloric diets, a low-fat or low-glycemic-load 
      diet for 3 months. Blood samples were taken pre- and postintervention. Serum 
      concentrations of interleukin-6 (IL-6), tumor necrosis factoralpha (TNF-alpha), 
      plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein-1 
      (MCP-1), and adipokines (leptin, resistin, and adiponectin) were analyzed using 
      multiplexed microsphere immunoassays. RESULTS: Weight loss was not different in 
      the low-fat (4.4%+/-3.8%) and low-glycemic-load (4.9%+/-3.2%) groups. Concentrations 
      of IL-6, TNF-alpha, PAI-1, and leptin were significantly reduced in both dietary 
      groups with no between-group differences, whereas MCP-1 and adiponectin 
      concentrations did not change. Subjects with full metabolic syndrome (three or 
      more components; n=109) experienced greater weight loss than subjects (n=72) with 
      one to two components and greater reduction in leptin [7.08 (95% confidence 
      interval 5.19, 8.97) vs. 3.46 (0.91, 6.00) ng/mL; p=0.02] and a tendency to 
      greater reduction in TNF-alpha (1.00 [0.60, 1.44] vs 0.40 [0.02, 0.78] pg/mL; 
      p=0.05). CONCLUSION: Hypocaloric diets improved inflammatory biomarkers and 
      adipokines independently of dietary composition. The response tended to be 
      greater in subjects with three or more components of metabolic syndrome than 
      their counterparts with one to two components.
FAU - Heggen, Eli
AU  - Heggen E
AD  - Department of Preventive Medicine, Preventive Cardiology, Oslo University 
      Hospital, Ulleval, Oslo, Norway. eli.heggen@uus.no
FAU - Klemsdal, Tor Ole
AU  - Klemsdal TO
FAU - Haugen, Fred
AU  - Haugen F
FAU - Holme, Ingar
AU  - Holme I
FAU - Tonstad, Serena
AU  - Tonstad S
LA  - eng
SI  - ClinicalTrials.gov/NCT00230919
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120813
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipokines/analysis/*blood
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis/*blood
MH  - *Diet, Carbohydrate-Restricted
MH  - *Diet, Fat-Restricted
MH  - Female
MH  - Glycemic Index/physiology
MH  - Humans
MH  - Inflammation/*blood/etiology
MH  - Male
MH  - Metabolic Syndrome/blood/*diet therapy/etiology
MH  - Middle Aged
MH  - Osmolar Concentration
MH  - Risk Factors
EDAT- 2012/08/15 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1089/met.2012.0012 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2012 Dec;10(6):437-42. doi: 10.1089/met.2012.0012. Epub 
      2012 Aug 13.