PMID- 22889566
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20130401
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 16
IP  - 2
DP  - 2013 Mar
TI  - Enhanced learning and memory of normal young rats by repeated oral administration 
      of Krill Phosphatidylserine.
PG  - 47-53
LID - 10.1179/1476830512Y.0000000029 [doi]
AB  - OBJECTIVE: Phosphatidylserine, a major acidic phospholipid in the brain, has been 
      studied extensively in regard to its actions on brain functions. The present 
      study examined the effects of Krill phosphatidylserine (Krill-PS) on the learning 
      and memory function and the neural activity in the normal young rats. METHODS: 
      The rats were administered saline or Krill-PS (Krill-PS 50, 100 mg/kg, per oral) 
      daily for 30 days. The cognitive improvement effect of Krill-PS on the normal 
      young rats was investigated by assessing the Morris water maze (MWM) test and by 
      insulin-like growth factor (IGF) and brain-derived neurotrophic factor (BDNF) 
      immunohistochemistry. A positron emission tomography (PET) scan was also 
      performed. RESULTS: Treatment with Krill-PS (100 mg/kg) produced a significant 
      improvement of the escape latency to find the platform in the MWM at the 3rd day 
      compared to that of the normal group. In the retention test, the Krill-PS100 
      group showed markedly increased time spent, distance, and crossing number around 
      the platform compared to that of the normal group. Consistent with the behavioral 
      data, the Krill-PS 100 group was significantly enhanced the BDNF and IGF 
      immuno-positive neurons in the hippocampal CA1. In the PET analysis, the glucose 
      uptake of the Krill-PS-treated groups was increased in the frontal lobe and 
      hippocampus. These results suggest that repeated Krill-PS treatment may be useful 
      for improving the cognitive function via regulation of neuronal growth factor 
      activity.
FAU - Park, Hyun-Jung
AU  - Park HJ
AD  - Acupuncture and Meridian Science Research Center, Kyung Hee University, 1 
      Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Shim, Hyun Soo
AU  - Shim HS
FAU - Kim, Kyung Soo
AU  - Kim KS
FAU - Han, Jeong-Jun
AU  - Han JJ
FAU - Kim, Jin Su
AU  - Kim JS
FAU - Ram Yu, A
AU  - Ram Yu A
FAU - Shim, Insop
AU  - Shim I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Phosphatidylserines)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Euphausiacea/*chemistry
MH  - Hippocampus/drug effects/metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Learning/*drug effects/physiology
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Neurons/drug effects/metabolism
MH  - Phosphatidylserines/administration & dosage/*pharmacology
MH  - Positron-Emission Tomography
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/08/15 06:00
MHDA- 2013/10/30 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - nns127 [pii]
AID - 10.1179/1476830512Y.0000000029 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2013 Mar;16(2):47-53. doi: 10.1179/1476830512Y.0000000029. Epub 
      2012 Aug 8.