PMID- 22889617
OWN - NLM
STAT- MEDLINE
DCOM- 20130624
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 12
IP  - 3
DP  - 2013 Jan
TI  - Diagnostic value of labial minor salivary gland biopsy for Sjogren's syndrome: a 
      systematic review.
PG  - 416-20
LID - S1568-9972(12)00165-6 [pii]
LID - 10.1016/j.autrev.2012.08.001 [doi]
AB  - OBJECTIVES: To assess the diagnostic value of minor salivary gland biopsy (MSGB) 
      for primary Sjogren's syndrome (pSS). METHODS: Systematic review of studies 
      retrieved from PUBMED and EMBASE using the terms 'salivary glands' AND 'Sjogren's 
      syndrome' AND 'biopsy', conducted in patients with suspected pSS, and defining 
      positive biopsies as a focus score (FS)>/=1. Sensitivity and specificity of MSGB 
      were abstracted from the articles or calculated when possible. RESULTS: Of 238 
      publications identified initially, 9 were included in the study. MSGB sensitivity 
      ranged from 63.5% to 93.7% and specificity from 61.2% to 100%. Specificity was 
      >89% in six studies. An attempt to separate patients with and without pSS without 
      using MSGB findings or via clinical re-evaluation was made in only two studies, 
      in 73 and 120 patients, respectively, with sicca syndrome in the first study and 
      suspected pSS in the other. The reference standard for diagnosing pSS was a set 
      of criteria that did not include MSGB in the first and patient re-evaluation by 
      three experienced rheumatologists who were aware of MSGB findings in the other. 
      In these studies, sensitivity was 63.9% and 85.7% and specificity was 91.9% and 
      89.7%, respectively. CONCLUSIONS: Few published studies have evaluated the 
      diagnostic usefulness of MSGB in pSS. Only two studies used a methodology that 
      precluded circular reasoning. Our study indicates a lack of information about the 
      diagnostic value of MSGB. Specificity and positive predictive values (PPV) are 
      high and sensitivity is variable.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Guellec, Dewi
AU  - Guellec D
AD  - Cavale Blanche Hospital, Rheumatology Unit, CHRU Hospital and Brittany 
      University, Brest, France.
FAU - Cornec, Divi
AU  - Cornec D
FAU - Jousse-Joulin, Sandrine
AU  - Jousse-Joulin S
FAU - Marhadour, Thierry
AU  - Marhadour T
FAU - Marcorelles, Pascale
AU  - Marcorelles P
FAU - Pers, Jacques-Olivier
AU  - Pers JO
FAU - Saraux, Alain
AU  - Saraux A
FAU - Devauchelle-Pensec, Valerie
AU  - Devauchelle-Pensec V
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20120807
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Biopsy
MH  - Humans
MH  - Salivary Glands, Minor/*pathology
MH  - Sensitivity and Specificity
MH  - Sjogren's Syndrome/*diagnosis/pathology
EDAT- 2012/08/15 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/07/15 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - S1568-9972(12)00165-6 [pii]
AID - 10.1016/j.autrev.2012.08.001 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2013 Jan;12(3):416-20. doi: 10.1016/j.autrev.2012.08.001. Epub 
      2012 Aug 7.