PMID- 22889715
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20120924
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 162
IP  - 3
DP  - 2012 Sep 28
TI  - Bone repair: new developments in growth factor delivery systems and their 
      mathematical modeling.
PG  - 502-20
LID - S0168-3659(12)00608-6 [pii]
LID - 10.1016/j.jconrel.2012.07.041 [doi]
AB  - More and more of our aging populations will suffer from large bone defects in the 
      next few years. But the growth factor (GF) delivery systems (DSs) currently under 
      investigation will help overcome the limitations of the bone grafts presently 
      used. Some GFDSs accredited by the Food and Drug Administration (FDA) are 
      commercially available, but they have mechanical, structural and GF retention 
      weaknesses. New studies focus on polymers and the composition of GFs in order to 
      mimic as closely as possible the physiological environment of healing bone. This 
      review first summarizes the process of endochondral bone healing and the major 
      cytokines involved. We then review the latest GFDSs, with their combinations of 
      organic, inorganic, natural and synthetic biomaterials, the kinetics of GF 
      release and their biological effects. We will explore new research avenues such 
      as the use of peptides derived from bone morphogenetic proteins, including our 
      own results, and the sequential release of bone-inducing GFs. We then review the 
      latest mathematical models of drug delivery systems (DDSs) for several transport 
      phenomena that may be encountered when using GFDS. The final section discusses 
      new improvements for GFDS modeling.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Lauzon, Marc-Antoine
AU  - Lauzon MA
AD  - Department of Chemical and Biotechnological Engineering, Universite de 
      Sherbrooke, 2500 Boul. de l'Universite, Sherbrooke, Quebec J1K 2R1, Canada.
FAU - Bergeron, Eric
AU  - Bergeron E
FAU - Marcos, Bernard
AU  - Marcos B
FAU - Faucheux, Nathalie
AU  - Faucheux N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120806
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Bone Regeneration
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*administration & dosage
MH  - *Models, Theoretical
EDAT- 2012/08/15 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/07/29 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - S0168-3659(12)00608-6 [pii]
AID - 10.1016/j.jconrel.2012.07.041 [doi]
PST - ppublish
SO  - J Control Release. 2012 Sep 28;162(3):502-20. doi: 10.1016/j.jconrel.2012.07.041. 
      Epub 2012 Aug 6.