PMID- 22890671
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20151119
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 115
DP  - 2013
TI  - Matricellular protein: a new player in cerebral vasospasm following subarachnoid 
      hemorrhage.
PG  - 213-8
LID - 10.1007/978-3-7091-1192-5_39 [doi]
AB  - INTRODUCTION: Matricellular protein (MCP) is a class of nonstructural and 
      secreted extracellular matrix proteins that exert diverse functions, but its role 
      in vascular smooth muscle contraction has not been investigated. MATERIAL AND 
      METHODS: First, rat subarachnoid hemorrhage (SAH) models were produced by 
      endovascular perforation and examined for tenascin-C (TNC) and osteopontin (OPN) 
      induction (representatives of MCPs) in vasospastic cerebral arteries using 
      immunostaining. Second, recombinant TNC (r-TNC), recombinant OPN (r-OPN), or both 
      were injected into a cisterna magna in healthy rats, and the effects on the 
      diameter of basilar arteries were determined using India ink angiography. 
      RESULTS: In SAH rats, TNC immunoreactivity was markedly induced in the smooth 
      muscle cell layers of spastic cerebral arteries on day 1 but not in control 
      animals. The TNC immunoreactivity decreased on day 3 as vasospasm improved: OPN 
      immunoreactivity, on the other hand, was more induced in the arterial wall on day 
      3. r-TNC injections caused prolonged contractions of rat basilar arteries, which 
      were reversed by r-OPN, although r-OPN itself had no effect on the vessel 
      diameter. CONCLUSIONS: MCPs, including TNC and OPN, may contribute to the 
      pathophysiology of cerebral vasospasm and provide a novel therapeutic approach 
      against it.
FAU - Suzuki, Hidenori
AU  - Suzuki H
AD  - Department of Neurosurgery, Mie University Graduate School of Medicine, Mie, 
      Japan. suzuki02@clin.medic.mie-u.ac.jp
FAU - Shiba, Masato
AU  - Shiba M
FAU - Fujimoto, Masashi
AU  - Fujimoto M
FAU - Kawamura, Kengo
AU  - Kawamura K
FAU - Nanpei, Mai
AU  - Nanpei M
FAU - Tekeuchi, Eriko
AU  - Tekeuchi E
FAU - Matsushima, Satoshi
AU  - Matsushima S
FAU - Kanamaru, Kenji
AU  - Kanamaru K
FAU - Imanaka-Yoshida, Kyoko
AU  - Imanaka-Yoshida K
FAU - Yoshida, Toshimichi
AU  - Yoshida T
FAU - Taki, Waro
AU  - Taki W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
RN  - 0 (Tenascin)
RN  - 0 (chinese ink)
RN  - 106441-73-0 (Osteopontin)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Animals
MH  - Basilar Artery/drug effects/metabolism/pathology
MH  - Carbon
MH  - Cerebral Angiography
MH  - Cisterna Magna/drug effects/physiopathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Neurologic Examination
MH  - Osteopontin/*metabolism/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Statistics, Nonparametric
MH  - Subarachnoid Hemorrhage/*complications/etiology
MH  - Tenascin/*metabolism/pharmacology
MH  - Time Factors
MH  - Vasoconstriction/drug effects
MH  - Vasospasm, Intracranial/*etiology/pathology
EDAT- 2012/08/15 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - 10.1007/978-3-7091-1192-5_39 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2013;115:213-8. doi: 10.1007/978-3-7091-1192-5_39.