PMID- 22891053
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1662-5129 (Electronic)
IS  - 1662-5129 (Linking)
VI  - 6
DP  - 2012
TI  - Comprehensive connectivity of the mouse main olfactory bulb: analysis and online 
      digital atlas.
PG  - 30
LID - 10.3389/fnana.2012.00030 [doi]
LID - 30
AB  - We introduce the first open resource for mouse olfactory connectivity data 
      produced as part of the Mouse Connectome Project (MCP) at UCLA. The MCP aims to 
      assemble a whole-brain connectivity atlas for the C57Bl/6J mouse using a double 
      coinjection tracing method. Each coinjection consists of one anterograde and one 
      retrograde tracer, which affords the advantage of simultaneously identifying 
      efferent and afferent pathways and directly identifying reciprocal connectivity 
      of injection sites. The systematic application of double coinjections potentially 
      reveals interaction stations between injections and allows for the study of 
      connectivity at the network level. To facilitate use of the data, raw images are 
      made publicly accessible through our online interactive visualization tool, the 
      iConnectome, where users can view and annotate the high-resolution, 
      multi-fluorescent connectivity data (www.MouseConnectome.org). Systematic double 
      coinjections were made into different regions of the main olfactory bulb (MOB) 
      and data from 18 MOB cases (~72 pathways; 36 efferent/36 afferent) currently are 
      available to view in iConnectome within their corresponding atlas level and their 
      own bright-field cytoarchitectural background. Additional MOB injections and 
      injections of the accessory olfactory bulb (AOB), anterior olfactory nucleus 
      (AON), and other olfactory cortical areas gradually will be made available. 
      Analysis of connections from different regions of the MOB revealed a novel, 
      topographically arranged MOB projection roadmap, demonstrated disparate MOB 
      connectivity with anterior versus posterior piriform cortical area (PIR), and 
      exposed some novel aspects of well-established cortical olfactory projections.
FAU - Hintiryan, Houri
AU  - Hintiryan H
AD  - Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of 
      Medicine, University of California, Los Angeles Los Angeles, CA, USA.
FAU - Gou, Lin
AU  - Gou L
FAU - Zingg, Brian
AU  - Zingg B
FAU - Yamashita, Seita
AU  - Yamashita S
FAU - Lyden, Hannah M
AU  - Lyden HM
FAU - Song, Monica Y
AU  - Song MY
FAU - Grewal, Arleen K
AU  - Grewal AK
FAU - Zhang, Xinhai
AU  - Zhang X
FAU - Toga, Arthur W
AU  - Toga AW
FAU - Dong, Hong-Wei
AU  - Dong HW
LA  - eng
GR  - P41 RR013642/RR/NCRR NIH HHS/United States
GR  - R01 MH094360/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20120807
PL  - Switzerland
TA  - Front Neuroanat
JT  - Frontiers in neuroanatomy
JID - 101477943
PMC - PMC3412993
OTO - NOTNLM
OT  - connectome
OT  - lateral olfactory tract
OT  - main olfactory bulb
OT  - neural tract tracing
OT  - online digital atlas
OT  - piriform cortical area
EDAT- 2012/08/15 06:00
MHDA- 2012/08/15 06:01
PMCR- 2012/01/01
CRDT- 2012/08/15 06:00
PHST- 2012/05/09 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/08/15 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fnana.2012.00030 [doi]
PST - epublish
SO  - Front Neuroanat. 2012 Aug 7;6:30. doi: 10.3389/fnana.2012.00030. eCollection 
      2012.