PMID- 22891507
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20191112
IS  - 0739-6686 (Print)
IS  - 0739-6686 (Linking)
VI  - 29
DP  - 2011
TI  - Shared genomics of type 2 and gestational diabetes mellitus.
PG  - 227-60
AB  - Gestational diabetes mellitus (GDM) is one of the most common complications of 
      pregnancy and the prevalence of GDM is increasing worldwide. Short- and long-term 
      complications of GDM on mothers and fetuses are well-recognized. These include 
      more than seven-fold higher risk for type 2 diabetes mellitus (T2DM) later in 
      life in women with GDM than those without. Evidence supports that GDM shares 
      several risk factors with T2DM, including genetic risks. This chapter reviewed 
      studies on candidate genes shared by T2DM and GDM published from 1990 to 2011. At 
      least 20 susceptible genes of T2DM have been studied in women with GDM in various 
      races. Results from current association studies on T2DM susceptible genes in GDM 
      have shown significant heterogeneity There may be primary evidence that 
      polymorphisms of susceptible genes of T2DM such as transcription factor 7-like 2 
      (TCF7L2) gene, potassium channel voltage-gate KQT-like subfamily member 1 (KCNQ1) 
      gene, and cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 
      1 (CDKAL1) gene, may increase risk of GDM. Associations between GDM and many 
      genetic variants have led to different findings across populations. Many genetic 
      polymorphisms related to GDM were investigated in a single study or a single 
      population. Replication studies to verify contributions of both common and rare 
      genetic variants for GDM and T2DM in specific racial/ethnic groups are needed.
FAU - Wung, Shu-Fen
AU  - Wung SF
AD  - College of Nursing, The University of Arizona, Tucson, USA.
FAU - Lin, Pei-Chao
AU  - Lin PC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nurs Res
JT  - Annual review of nursing research
JID - 8406387
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics/*nursing
MH  - Diabetes, Gestational/*genetics/*nursing
MH  - Female
MH  - Genomics/*trends
MH  - Humans
MH  - Pregnancy
EDAT- 2011/01/01 00:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1891/0739-6686.29.227 [doi]
PST - ppublish
SO  - Annu Rev Nurs Res. 2011;29:227-60. doi: 10.1891/0739-6686.29.227.