PMID- 22891509
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20211021
IS  - 0739-6686 (Print)
IS  - 0739-6686 (Linking)
VI  - 29
DP  - 2011
TI  - Type 2 diabetes, genomics, and nursing: necessary next steps to advance the 
      science into improved, personalized care.
PG  - 281-302
AB  - Type 2 diabetes mellitus (T2DM) is an inherited, chronic disorder with long-term 
      complications; including cardiovascular disease the leading cause of mortality in 
      the United States. The prevalence of T2DM and its complications are on the rise 
      in the United States, highlighting the need for improved individualized 
      prevention and treatment strategies. Exciting advancements in the field of 
      genomics has led to the recent discovery of numerous genetic markers for T2DM; 
      completing a promising first step toward improved, individualized prevention and 
      treatment strategies for T2DM. These genomic markers, identified using 
      genome-wide association studies (GWAS), candidate gene, and rare variant 
      methodology, identify new physiologic pathways underlying the development of 
      T2DM. Much more work is needed to successfully translate the identification of 
      genetic markers for T2DM into improved, individualized prevention and treatment 
      strategies. As front line providers and leaders of prevention and treatment 
      strategies for chronic disease, nurses, nurse practitioners, and nurse scientists 
      must contribute to this translational effort. Thus, it is important for nurses at 
      all levels to (a) be aware of the current science of genetics and T2DM and (b) 
      participate in the translation of this genetic information into improved, 
      personalized patient care. The aim of this review is to (a) provide an overview 
      of the current state of the science of genetic markers and T2DM and (b) highlight 
      essential next steps to successfully translate the identification of genetic 
      markers for T2DM into improved prevention and treatment strategies; focusing 
      particularly on the role of nursing in this process.
FAU - Underwood, Patricia C
AU  - Underwood PC
AD  - Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
LA  - eng
GR  - F32 NR013318/NR/NINR NIH HHS/United States
GR  - T32 HL007609/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nurs Res
JT  - Annual review of nursing research
JID - 8406387
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics/*nursing
MH  - Genetic Diseases, Inborn/epidemiology/genetics/nursing
MH  - Genomics/*trends
MH  - Humans
MH  - Patient-Centered Care/*trends
MH  - Precision Medicine/*trends
MH  - Risk Factors
EDAT- 2011/01/01 00:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1891/0739-6686.29.281 [doi]
PST - ppublish
SO  - Annu Rev Nurs Res. 2011;29:281-302. doi: 10.1891/0739-6686.29.281.