PMID- 22892832
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20211021
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 461
IP  - 4
DP  - 2012 Oct
TI  - Morphological and molecular characteristics of nested melanoma of the elderly 
      (evolved lentiginous melanoma).
PG  - 433-9
LID - 10.1007/s00428-012-1293-0 [doi]
AB  - We identified a group of melanocytic lesions with an architectural pattern very 
      similar to that of a junctional nevus: cells mostly grouped in distinct nests, 
      more or less of the same size and shape, and regularly distributed along the 
      dermoepidermal junction. In contrast with these nevus-like features, these 
      neoplasms display additional details which are incompatible with a diagnosis of 
      junctional nevus. These include areas of lentiginous array with focal pagetoid 
      spread of melanocytes above the junction; marked cytological atypia, such as 
      nuclear enlargement, hyperchromasia, nuclear membrane thickening and with a mild 
      degree of cellular pleomorphism. Moreover, these lesions mostly developed on 
      severely sun-damaged skin of old patients. Using a four-probe fluorescence in 
      situ hybridization (FISH) assay targeting RREB1, MYB, Cep6, and CCND1, we found 
      that seven of the eight propositus cases showed chromosomal aberrations 
      consistent with the standardized FISH diagnostic criteria for melanoma. Instead, 
      the five junctional nevi that served as controls were negative in this test. 
      These findings underline the utility of correlating clinical-pathological 
      observations with FISH analysis for diagnosing correctly as melanoma these 
      malignant neoplasms, which closely simulate a junctional nevus.
FAU - Pennacchia, Ilaria
AU  - Pennacchia I
AD  - Department of Pathology, Catholic University Medical School, Rome, Italy. 
      ilaria.pennacchia@libero.it
FAU - Garcovich, Simone
AU  - Garcovich S
FAU - Gasbarra, Rita
AU  - Gasbarra R
FAU - Leone, Alvaro
AU  - Leone A
FAU - Arena, Vincenzo
AU  - Arena V
FAU - Massi, Guido
AU  - Massi G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120815
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - Epidermal Nevus
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Nucleus/pathology
MH  - Chromosome Aberrations
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma/diagnosis/*genetics/*pathology
MH  - Middle Aged
MH  - Nevus
MH  - Nevus, Pigmented/diagnosis/genetics/*pathology
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Skin Neoplasms/diagnosis/*genetics/*pathology
EDAT- 2012/08/16 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1007/s00428-012-1293-0 [doi]
PST - ppublish
SO  - Virchows Arch. 2012 Oct;461(4):433-9. doi: 10.1007/s00428-012-1293-0. Epub 2012 
      Aug 15.