PMID- 22893258
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20220408
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 45
IP  - 1
DP  - 2013 Jan
TI  - Salivary cortisol day curves in Addison's disease in patients on hydrocortisone 
      replacement.
PG  - 62-8
LID - 10.1055/s-0032-1321855 [doi]
AB  - Using salivary cortisol (SC) measurements, cortisol exposure in Addison's disease 
      patients on hydrocortisone replacement was determined and compared with healthy 
      controls. Cortisol pharmacokinetics was assessed in 31 patients with Addison's 
      disease on replacement hydrocortisone doses (median daily dose 20 mg; range 5-50 
      mg) and 30 healthy control subjects. Saliva samples (n=16) were collected between 
      08:00 and 00:00 h in 1 day, using a passive drool technique. Cortisol exposure 
      was evaluated by noncompartmental approach. In the patients, cortisol exposure 
      was significantly higher than in controls: median inter-quartile range (IQR) peak 
      cortisol (C(max)) 174.5 (59.3-837.0) vs. 6.50 (4.7-19.3) nmol/l, p=0.0001; area 
      under the curve (AUC) 390.1 (177.1-928.9) vs. 21.4 (14.6-28.4) minutes*nmol/l, 
      p=0.0001, trough cortisol level (C(min)) 0.49 (0.49-0.96) vs. 0.49 (0.49-0.49) 
      nmol/l, p=0.02, occurring at 480.0 (0.1-660.0) vs. 405.0 (180.0-570.0) min, 
      p=0.56. First peak cortisol was 174.5 (53.0-754.7) vs. 6.27 (3.90-8.47) nmol/l, 
      p=0.0001 and second peak cortisol 18.90 (5.22-76.9) vs. 3.12 (1.76-4.79) nmol/l, 
      p=0.0001. The time to first peak cortisol differed between the 2 groups, 30 
      (30-75) vs. 0.1 (0.1-30) minutes; p=0.0001. At doses studied, hydrocortisone 
      replacement therapy results in cortisol pharmacokinetics being markedly different 
      from endogenous cortisol profiles in healthy control subjects. Addison's disease 
      patients had significantly higher SC levels compared to healthy control subjects.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Ross, I L
AU  - Ross IL
AD  - Division of Endocrinology, Department of Medicine University of Cape Town, South 
      Africa.
FAU - Levitt, N S
AU  - Levitt NS
FAU - Van der Walt, J S
AU  - Van der Walt JS
FAU - Schatz, D A
AU  - Schatz DA
FAU - Johannsson, G
AU  - Johannsson G
FAU - Haarburger, D H
AU  - Haarburger DH
FAU - Pillay, T S
AU  - Pillay TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120814
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Addison Disease/*drug therapy/*metabolism
MH  - Adult
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - *Hormone Replacement Therapy
MH  - Humans
MH  - Hydrocortisone/administration & dosage/*pharmacokinetics/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Saliva/*metabolism
MH  - Young Adult
EDAT- 2012/08/16 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.1055/s-0032-1321855 [doi]
PST - ppublish
SO  - Horm Metab Res. 2013 Jan;45(1):62-8. doi: 10.1055/s-0032-1321855. Epub 2012 Aug 
      14.