PMID- 22897207
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20240322
IS  - 2159-3345 (Electronic)
IS  - 2159-3337 (Print)
IS  - 2159-3337 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Aug
TI  - Antiproliferative activity of novel thiopyran analogs on MCF-7 breast and HCT-15 
      colon cancer cells: synthesis, cytotoxicity, cell cycle analysis, and 
      DNA-binding.
PG  - 265-70
LID - 10.1089/nat.2012.0346 [doi]
AB  - A series of 6H-thiopyran-2,3-dicarboxylate derivatives 4a-d were synthesized and 
      evaluated for their cytotoxic effect against HCT-15 colon and MCF-7 breast cancer 
      cell lines using Sulforhodamine B (SRB) assay. The results showed that these 
      compounds could exhibit a good cytotoxicity to both cell lines. In addition, 
      these compounds were found to exhibit significant DNA-binding affinity. 
      Ultraviolet-visible light (UV-Vis) spectroscopy was conducted to determine the 
      ability of the ligand under analysis. The effect of ligand complexation on DNA 
      structure led to overall affinity constants of K(4a)=3.5x10(4) M(-1), 
      K(4b)=6.4x10(4) M(-1), K(4c)=3.2x10(4) M(-1), and K(4d)=2.4x10(4) M(-1). Our 
      findings could provide new evidence showing the relationship between the chemical 
      structure and biological activity and may be useful for the discovery of new 
      anti-cancer drugs.
FAU - Tavakolinia, Fatemeh
AU  - Tavakolinia F
AD  - Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
FAU - Baghipour, Tayebeh
AU  - Baghipour T
FAU - Hossaini, Zinatossadat
AU  - Hossaini Z
FAU - Zareyee, Daryoush
AU  - Zareyee D
FAU - Khalilzadeh, Mohammad A
AU  - Khalilzadeh MA
FAU - Rajabi, Mehdi
AU  - Rajabi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - United States
TA  - Nucleic Acid Ther
JT  - Nucleic acid therapeutics
JID - 101562758
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Pyrans)
RN  - 0 (Sulfhydryl Compounds)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology
MH  - Apoptosis/drug effects
MH  - Breast Neoplasms
MH  - Cell Cycle/*drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*drug effects
MH  - Cell Shape/drug effects
MH  - Colonic Neoplasms
MH  - DNA/*chemistry
MH  - Drug Screening Assays, Antitumor
MH  - Female
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Pyrans/chemical synthesis/chemistry/*pharmacology
MH  - Sulfhydryl Compounds/chemical synthesis/chemistry/*pharmacology
PMC - PMC3426206
EDAT- 2012/08/18 06:00
MHDA- 2012/12/27 06:00
PMCR- 2012/08/01
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.1089/nat.2012.0346 [pii]
AID - 10.1089/nat.2012.0346 [doi]
PST - ppublish
SO  - Nucleic Acid Ther. 2012 Aug;22(4):265-70. doi: 10.1089/nat.2012.0346. Epub 2012 
      Aug 16.