PMID- 22898613
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20231213
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 50
IP  - 11
DP  - 2012 Nov
TI  - Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic 
      enzyme mapping assay in isoproterenol-induced myocardial ischemic rats.
PG  - 3971-7
LID - S0278-6915(12)00552-2 [pii]
LID - 10.1016/j.fct.2012.07.067 [doi]
AB  - This study investigates the antihyperlipidemic effect of ursolic acid (UA) on 
      isoproterenol (ISO) induced male albino Wistar rats. Myocardial ischemia was 
      induced by subcutaneous injection of ISO (85 mg/kg BW) twice at an interval of 24 
      h, for two consecutive days. A significant increase in the activities of the 
      serum marker enzymes [creatine kinase, creatine kinase-MB and lactate 
      dehydrogenease (LDH)], a prominent expression of LDH 1 and LDH 2 isoenzymes, 
      increased levels of plasma total cholesterol (TC), low density 
      lipoprotein-cholesterol, very low density lipoprotein-cholesterol, triglycerides 
      (TG), free fatty acids (FFA), phospholipids (PL) and atherogenic index and 
      decreased level of high density lipoprotein-cholesterol were observed in 
      ISO-induced rats. The levels of TC, TG and FFA increased and the level of PL 
      decreased in the heart tissue of ISO-induced rats. Further, there was an 
      increased DNA damage (Comet assay) and myocardium infarct size as observed by 
      staining with triphenyltetrazolium chloride (TTC). UA was administered 
      subcutaneously for 7 days at a dose of 40 mg/kg BW. UA administration to ischemic 
      rats brought all these parameters to near normality showing the protective effect 
      of UA on ISO-induced rats.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Radhiga, Thangaiyan
AU  - Radhiga T
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar 608 002, Tamilnadu, India.
FAU - Rajamanickam, Chellam
AU  - Rajamanickam C
FAU - Senthil, Selvaraj
AU  - Senthil S
FAU - Pugalendi, Kodukkur Viswanathan
AU  - Pugalendi KV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120807
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Biomarkers)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Cholesterol, VLDL)
RN  - 0 (Phospholipids)
RN  - 0 (Triterpenes)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Biomarkers/*analysis/metabolism
MH  - Cardiotonic Agents/*pharmacology
MH  - Cholesterol/blood
MH  - Cholesterol, LDL/blood/metabolism
MH  - Cholesterol, VLDL/blood
MH  - Creatine Kinase, MB Form/blood
MH  - DNA Damage/drug effects
MH  - Heart/drug effects
MH  - Isoproterenol/*toxicity
MH  - L-Lactate Dehydrogenase/blood
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Myocardial Infarction/drug therapy/metabolism
MH  - Myocardial Ischemia/chemically induced/*drug therapy/enzymology/*metabolism
MH  - Myocardium/metabolism
MH  - Phospholipids/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Triterpenes/*pharmacology
MH  - Ursolic Acid
EDAT- 2012/08/18 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/06/01 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - S0278-6915(12)00552-2 [pii]
AID - 10.1016/j.fct.2012.07.067 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2012 Nov;50(11):3971-7. doi: 10.1016/j.fct.2012.07.067. Epub 
      2012 Aug 7.