PMID- 22899757
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20220318
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Sep 14
TI  - "En face" OCT imaging of the IS/OS junction line in type 2 idiopathic macular 
      telangiectasia.
PG  - 6145-52
AB  - PURPOSE: We investigated abnormalities of the photoreceptor inner/outer segment 
      (IS/OS) junction layer viewed "en face" and their functional correlates in type 2 
      idiopathic macular telangiectasia (type 2 MacTel). METHODS: Segmentation and "en 
      face" imaging of the IS/OS lines in spectral domain optical coherence tomographic 
      (SD-OCT) volumes were performed manually. Mesopic retinal sensitivity thresholds 
      were determined using a Nidek MP1 microperimeter. "En face" SD-OCT images and 
      microperimetric data were superimposed over images of the fundus. Retinal 
      structure and characteristics of type 2 MacTel were analyzed, and associations of 
      structural changes with function were investigated. RESULTS: We examined 49 eyes 
      of 28 patients (mean age 62.6 +/- 9.4 years). Total IS/OS break area ranged from 
      0.04 to 2.23 mm(2) (mean 0.63 mm(2), SD 0.53 mm(2)) and 0.03 to 1.49 mm(2) (mean 0.49 
      mm(2), SD 0.42 mm(2)) in right and left eyes, respectively. A correlation between 
      fellow eyes was present (Spearman correlation rho = 0.770, P < 0.01). An assessment 
      of the repeatability of IS/OS lesion area measurements (n = 19 eyes) revealed an 
      intra-class correlation coefficient of 0.99 (95% confidence interval [CI] of 
      0.975-0.996). Retinal areas corresponding to an IS/OS break showed a mean retinal 
      sensitivity of 8.3 +/- 5.8 and 8.7 +/- 5.7 decibels (dB) in right and left eyes, 
      respectively. Mean sensitivity over retinal areas outside the lesion was 
      significantly higher, 17.0 +/- 3.3 and 16.7 +/- 3.6 dB in right and left eyes, 
      respectively (paired t-test, P < 0.01). Mean aggregate retinal sensitivity loss 
      was 33.5 +/- 30.4 dB (n = 40), correlating well with IS/OS lesion area (Pearson 
      correlation coefficient = 0.848, P < 0.01). CONCLUSIONS: "En face" OCT imaging of 
      the IS/OS junction layer provides a functionally relevant method for assessing 
      disease severity in type 2 MacTel.
FAU - Sallo, Ferenc B
AU  - Sallo FB
AD  - The Reading Centre, Department of Research and Development, Moorfields Eye 
      Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK. 
      Ferenc.Sallo@moorfields.nhs.uk
FAU - Peto, Tunde
AU  - Peto T
FAU - Egan, Catherine
AU  - Egan C
FAU - Wolf-Schnurrbusch, Ute E K
AU  - Wolf-Schnurrbusch UE
FAU - Clemons, Traci E
AU  - Clemons TE
FAU - Gillies, Mark C
AU  - Gillies MC
FAU - Pauleikhoff, Daniel
AU  - Pauleikhoff D
FAU - Rubin, Gary S
AU  - Rubin GS
FAU - Chew, Emily Y
AU  - Chew EY
FAU - Bird, Alan C
AU  - Bird AC
CN  - MacTel Study Group
LA  - eng
GR  - P30 EY014800/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120914
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Telangiectasis/*diagnosis/physiopathology
MH  - Sensory Thresholds/physiology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
PMC - PMC4608676
COIS- Disclosure: F.B. Sallo, None; T. Peto, None; C. Egan, None; U.E.K. 
      Wolf-Schnurrbusch, None; T.E Clemons, None; M.C. Gillies, None; D. Pauleikhoff, 
      None; G.S. Rubin, None; E.Y. Chew, None; A.C. Bird, None
FIR - Sahel, Jose-Alain
IR  - Sahel JA
FIR - Guymer, Robyn
IR  - Guymer R
FIR - Soubrane, Gisele
IR  - Soubrane G
FIR - Gaudric, Alain
IR  - Gaudric A
FIR - Schwartz, Steven
IR  - Schwartz S
FIR - Constable, Ian
IR  - Constable I
FIR - Cooney, Michael
IR  - Cooney M
FIR - Egan, Catherine
IR  - Egan C
FIR - Singerman, Lawrence
IR  - Singerman L
FIR - Gillies, Mark C
IR  - Gillies MC
FIR - Friedlander, Martin
IR  - Friedlander M
FIR - Pauleikhoff, Daniel
IR  - Pauleikhoff D
FIR - Moisseiev, Joseph
IR  - Moisseiev J
FIR - Rosen, Richard
IR  - Rosen R
FIR - Murphy, Robert
IR  - Murphy R
FIR - Holz, Frank
IR  - Holz F
FIR - Comer, Grant
IR  - Comer G
FIR - Blodi, Barbara
IR  - Blodi B
FIR - Do, Diana
IR  - Do D
FIR - Brucker, Alexander
IR  - Brucker A
FIR - Narayanan, Raja
IR  - Narayanan R
FIR - Wolf, Sebastian
IR  - Wolf S
FIR - Rosenfeld, Philip
IR  - Rosenfeld P
FIR - Bernstein, Paul S
IR  - Bernstein PS
FIR - Miller, Joan W
IR  - Miller JW
EDAT- 2012/08/18 06:00
MHDA- 2012/12/10 06:00
PMCR- 2012/09/01
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - iovs.12-10580 [pii]
AID - 10.1167/iovs.12-10580 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Sep 14;53(10):6145-52. doi: 
      10.1167/iovs.12-10580.