PMID- 22901182
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 5
DP  - 2012
TI  - G1/S-specific cyclin-D1 might be a prognostic biomarker for patients with 
      laryngeal squamous cell carcinoma.
PG  - 2133-7
AB  - OBJECTIVE: To investigate the prognostic role of antigen KI-67 (Ki-67) and 
      G1/S-specific cyclin-D1 (cyclin-D1) in patients with laryngeal squamous cell 
      carcinoma (LSCC). METHODS: Immunohistochemical staining (IHS) was used to 
      determine the protein expression of Ki-67 and cyclin-D1 in LSCC tissues. 
      Kaplan-Meier survival curves was calculated with reference to Ki-67 and cyclin-D1 
      levels. RESULTS: Cyclin-D1 and Ki67 were expressed in the nuclei of cancer cells. 
      Among the total of 92 cancer tissues examined by immunohistochemistry, 60 
      (65.22%) had cyclin-D1 overexpression and 56 (60.87%) had Ki67 overexpression. 
      Cyclin-D1 overexpression is associated with the advanced stage of the cancer 
      (P=0.029), but not with gender, age, stage of cancer, histological 
      differentiation, anatomical site, smoking history and alcohol consumption 
      history. Ki67 overexpression is not associated with the advanced stage, gender, 
      age, histological differentiation, anatomical site, smoking history and alcohol 
      consumption history. A statistically significant correlation was found between 
      lymph node status and the expression of Ki67 (p=0.025). Overexpression of 
      cyclin-D1 was correlated to shorter relapse-free survival period (P<0.001). 
      CONCLUSIONS: Overexpression of cyclin-D1 can be used as a marker to predict 
      relapse in patients with LSCC after primary curative resection.
FAU - Zhang, Ying-Yao
AU  - Zhang YY
AD  - Department of Otolaryngology-Head and Neck Surgery, Qi-Lu Hospital, Shandong 
      University, Jinan, China.
FAU - Xu, Zhi-Na
AU  - Xu ZN
FAU - Wang, Jun-Xi
AU  - Wang JX
FAU - Wei, Dong-Min
AU  - Wei DM
FAU - Pan, Xin-Liang
AU  - Pan XL
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCND1 protein, human)
RN  - 0 (Ki-67 Antigen)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cyclin D1/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - G1 Phase/*physiology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Ki-67 Antigen/metabolism
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*metabolism/mortality/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - S Phase/*physiology
MH  - Survival Rate
EDAT- 2012/08/21 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.7314/apjcp.2012.13.5.2133 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(5):2133-7. doi: 10.7314/apjcp.2012.13.5.2133.