PMID- 2290166
OWN - NLM
STAT- MEDLINE
DCOM- 19910403
LR  - 20131121
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 17
IP  - 9
DP  - 1990 Sep
TI  - Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus 
      erythematosus and urticarial vasculitis in a patient with C2 deficiency.
PG  - 1222-5
AB  - The deficiency of second component of complement (C2d) is the most common 
      hereditary complement deficiency. Patients with C2 deficiency are frequently 
      associated with an auto-immune disease process, in particular, systemic lupus 
      erythematosus (LE)-like syndrome and/or vasculitic syndrome or bacterial 
      infections. C2d has been associated with the LE subset of subacute cutaneous LE 
      (SCLE), the presence of anti-Ro (SSA) antibodies, and the human leukocyte antigen 
      (HLA) types A10, B18, DR2. We describe the clinical, serologic and immunogenetic 
      data in a patient with manifestations of Sjogren's syndrome who developed 
      urticarial vasculitis and photosensitive annular SCLE which were effectively 
      treated with oral dapsone. Our case illustrates the dynamic nature of LE.
FAU - Holtman, J H
AU  - Holtman JH
AD  - School of Medicine, University of Louisville, KY.
FAU - Neustadt, D H
AU  - Neustadt DH
FAU - Klein, J
AU  - Klein J
FAU - Callen, J P
AU  - Callen JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Complement C2)
RN  - 8W5C518302 (Dapsone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Complement C2/*deficiency
MH  - Dapsone/administration & dosage/*therapeutic use
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/complications/*drug therapy/metabolism/pathology
MH  - Sjogren's Syndrome/complications/metabolism/pathology
MH  - Urticaria/complications
MH  - Vasculitis/complications/*drug therapy/metabolism/pathology
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1990 Sep;17(9):1222-5.