PMID- 22901763
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20131121
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - The Val66Met polymorphism of the BDNF gene influences trigeminal pain-related 
      evoked responses.
PG  - 866-73
LID - 10.1016/j.jpain.2012.05.014 [doi]
AB  - Cortical pain processing is associated with large-scale changes in neuronal 
      connectivity, resulting from neural plasticity phenomena of which brain-derived 
      neurotrophic factor (BDNF) is a central driver. The common single nucleotide 
      polymorphism Val66Met is associated with reduced BDNF activity. Using the 
      trigeminal pain-related evoked potential (tPREP) to repeated electrical painful 
      stimuli, we investigated whether the methionine substitution at codon 66 of the 
      BDNF gene was associated with changes in cortical processing of noxious stimuli. 
      Fifty healthy volunteers were genotyped: 30 were Val/Val and 20 were 
      Met-carriers. tPREPs to 30 stimuli of the right supraorbital nerve using a 
      concentric electrode were recorded. The N2 and P2 component latencies and the 
      N2-P2 amplitude were measured over the 30 stimuli and separately, by dividing the 
      measurements in 3 consecutive blocks of 10 stimuli. The average response to the 
      30 stimuli did not differ in latency or amplitude between the 2 genotypes. There 
      was a decrease in the N2-P2 amplitude between first and third block in the 
      Val/Val group but not in Met-carriers. BDNF Val66Met is associated with reduced 
      decremental response to repeated electrical stimuli, possibly as a result of 
      ineffective mechanisms of synaptic memory and brain plasticity associated with 
      the polymorphism. PERSPECTIVE: BDNF Val66Met polymorphism affects the tPREP N2-P2 
      amplitude decrement and influences cortical pain processing through 
      neurotrophin-induced neural plasticity, or through a direct BDNF 
      neurotransmitter-like effect. Our findings suggest that upcoming BDNF central 
      agonists might in the future play a role in pain management.
CI  - Copyright (c) 2012 American Pain Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Di Lorenzo, Cherubino
AU  - Di Lorenzo C
AD  - Don Carlo Gnocchi Onlus Foundation, Milan, Italy. cherub@inwind.it
FAU - Di Lorenzo, Giorgio
AU  - Di Lorenzo G
FAU - Daverio, Andrea
AU  - Daverio A
FAU - Pasqualetti, Patrizio
AU  - Pasqualetti P
FAU - Coppola, Gianluca
AU  - Coppola G
FAU - Giannoudas, Ioannis
AU  - Giannoudas I
FAU - Barone, Ylenia
AU  - Barone Y
FAU - Grieco, Gaetano S
AU  - Grieco GS
FAU - Niolu, Cinzia
AU  - Niolu C
FAU - Pascale, Esterina
AU  - Pascale E
FAU - Santorelli, Filippo M
AU  - Santorelli FM
FAU - Nicoletti, Ferdinando
AU  - Nicoletti F
FAU - Pierelli, Francesco
AU  - Pierelli F
FAU - Siracusano, Alberto
AU  - Siracusano A
FAU - Seri, Stefano
AU  - Seri S
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120814
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Electric Stimulation/adverse effects
MH  - Electroencephalography
MH  - Evoked Potentials/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Pain/*etiology
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Sex Factors
MH  - Trigeminal Nerve/physiopathology
MH  - Valine/*genetics
MH  - Young Adult
EDAT- 2012/08/21 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/05/06 00:00 [received]
PHST- 2012/05/30 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - S1526-5900(12)00687-6 [pii]
AID - 10.1016/j.jpain.2012.05.014 [doi]
PST - ppublish
SO  - J Pain. 2012 Sep;13(9):866-73. doi: 10.1016/j.jpain.2012.05.014. Epub 2012 Aug 
      14.