PMID- 22902134
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20151119
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 106
IP  - 11
DP  - 2012 Nov
TI  - Risk of new onset diabetes mellitus in patients with asthma or COPD taking 
      inhaled corticosteroids.
PG  - 1487-93
LID - S0954-6111(12)00273-9 [pii]
LID - 10.1016/j.rmed.2012.07.011 [doi]
AB  - BACKGROUND: A recent case-controlled study reported an increased risk of diabetes 
      mellitus in patients treated with inhaled corticosteroids for asthma or COPD, 
      versus age-matched controls. OBJECTIVE: The purpose of the current study was to 
      evaluate whether there was an increased risk of new onset diabetes mellitus or 
      hyperglycaemia among patients with asthma or COPD treated with inhaled 
      corticosteroids. METHODS: A retrospective analysis evaluated all double-blind, 
      placebo-controlled, trials in patients >/=4 years of age involving budesonide or 
      budesonide/formoterol in asthma (26 trials; budesonide: n = 9067; placebo: 
      n = 5926), and in COPD (8 trials; budesonide: n = 4616; non-ICS: n = 3643). A 
      secondary dataset evaluated all double-blind, controlled trials in asthma 
      involving the use of inhaled corticosteroids (60 trials; budesonide: n = 33,496; 
      fluticasone: n = 2773). RESULTS: In the primary asthma dataset, the occurrence of 
      diabetes mellitus/hyperglycaemia adverse events (AEs) was 0.13% for budesonide 
      and 0.13% for placebo (HR 0.98 [95% CI: 0.38-2.50], p = 0.96) and serious adverse 
      events (SAEs) was 0% for budesonide and 0.05% for placebo. In the secondary 
      dataset, the occurrence of diabetes/hyperglycaemia as AE and SAE was 0.19% and 
      0.03%, respectively. In the COPD dataset, the occurrence of diabetes 
      mellitus/hyperglycaemia AEs was 1.3% for budesonide and 1.2% for non-ICS (HR 0.99 
      [95% CI: 0.67-1.46], p = 0.96) and SAEs was 0.1% for budesonide and 0.03% for 
      non-ICS. CONCLUSION AND CLINICAL RELEVANCE: Treatment with inhaled 
      corticosteroids in patients with asthma or COPD was not associated with increased 
      risk of new onset diabetes mellitus or hyperglycaemia.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - O'Byrne, P M
AU  - O'Byrne PM
AD  - Firestone Institute of Respiratory Health, Michael G DeGroote School of Medicine, 
      McMaster University, Hamilton, Ontario, Canada. obyrnep@mcmaster.ca
FAU - Rennard, S
AU  - Rennard S
FAU - Gerstein, H
AU  - Gerstein H
FAU - Radner, F
AU  - Radner F
FAU - Peterson, S
AU  - Peterson S
FAU - Lindberg, B
AU  - Lindberg B
FAU - Carlsson, L-G
AU  - Carlsson LG
FAU - Sin, D D
AU  - Sin DD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120815
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Androstadienes)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Ethanolamines)
RN  - 51333-22-3 (Budesonide)
RN  - CUT2W21N7U (Fluticasone)
RN  - W34SHF8J2K (Formoterol Fumarate)
SB  - IM
MH  - Administration, Inhalation
MH  - Adrenal Cortex Hormones/administration & dosage/*adverse effects
MH  - Adult
MH  - Androstadienes/administration & dosage/adverse effects
MH  - Anti-Asthmatic Agents/administration & dosage/*adverse effects
MH  - Asthma/*drug therapy
MH  - Budesonide/administration & dosage/adverse effects
MH  - Diabetes Mellitus/*chemically induced
MH  - Double-Blind Method
MH  - Ethanolamines/administration & dosage/adverse effects
MH  - Fluticasone
MH  - Formoterol Fumarate
MH  - Humans
MH  - Hyperglycemia/chemically induced
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - Randomized Controlled Trials as Topic
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2012/08/21 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/07/19 00:00 [revised]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S0954-6111(12)00273-9 [pii]
AID - 10.1016/j.rmed.2012.07.011 [doi]
PST - ppublish
SO  - Respir Med. 2012 Nov;106(11):1487-93. doi: 10.1016/j.rmed.2012.07.011. Epub 2012 
      Aug 15.