PMID- 22903662
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20201216
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Naturally occurring IgM antibodies to oxidation-specific epitopes.
PG  - 2-13
LID - 10.1007/978-1-4614-3461-0_1 [doi]
AB  - Naturally occurring antibodies (NAbs) have specificity for both microbial and 
      self antigens, which allows them to act in the first line defense against 
      invading pathogens, as well as in tissue homeostasis by mediating the clearance 
      of cellular debris. This latter recognition of self by NAbs was often thought to 
      reflect the polyreactivity of low affinity antibodies. The finding that 
      oxidation-specific epitopes are dominant targets of naturally occurring IgM 
      antibodies shed light on this and provided novel insights into the understanding 
      of the house keeping functions of NAbs. Oxidation-specific epitopes represent 
      stress-induced or altered self structures that are generated as a consequence of 
      lipidperoxidation during many physiological and pathological situations. 
      Importantly, the same structures have been found in the membranes of dying cells. 
      Only oxidized lipids and dying cells-but not native membrane lipids or viable 
      cells-are recognized by this set of NAbs. Thus, oxidation-specific epitopes 
      represent ideal marks that identify biological waste for its clearance and the 
      neutralization of its pro-inflammatory properties. Furthermore, this binding 
      property of NAbs has also important implications for various chronic inflammatory 
      diseases, including atherosclerosis.
FAU - Binder, Christoph J
AU  - Binder CJ
AD  - Department of Laboratory Medicine, Medical University of Vienna, Austria. 
      christoph.binder@meduniwien.ac.at
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - Antibody Affinity
MH  - Autoantibodies/*immunology
MH  - Autoantigens/*immunology
MH  - Cardiovascular Diseases/immunology
MH  - Cellular Senescence/immunology
MH  - Epitopes/immunology
MH  - Homeostasis/immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Immunoglobulin M/*immunology
MH  - Inflammation/immunology
MH  - Lipid Peroxidation/immunology
MH  - Oxidation-Reduction
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_1 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:2-13. doi: 10.1007/978-1-4614-3461-0_1.