PMID- 22903663
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Naturally occurring autoantibodies to apoptotic cells.
PG  - 14-26
LID - 10.1007/978-1-4614-3461-0_2 [doi]
AB  - Subsets of IgM naturally occurring autoantibodies (NAbs) bind to the cell surface 
      membranes of dying cells. The antibodies predominantly have specificities against 
      lipid antigens or oxidized lipids. Chief among these lipid antigens are 
      phosphorylcholine (PC) and malondialdehyde (MDA). Antibodies to negatively 
      charged phospholipids such as phosphatidylserine (PS) have been described and 
      there is controversy as to whether these antibodies are related to 
      anticardiolipin antibodies observed in disease states. IgM NAbs that bind to 
      apoptotic cells recruit classical complement pathway components and facilitate 
      phagocytosis by both macrophages and dendritic cells, and may block inflammatory 
      pathways. Under these circumstances, pathologic immune responses to self 
      (autoimmunity) are avoided, whereas mice lacking serum IgM develop a lupus-like 
      disease with associated IgG autoantibody responses. Based on these observations, 
      IgM anti-PC NAbs were found to attenuate inflammation in mouse models of 
      arthritis. IgMNAbs antibodies therefore appear to play pivotal roles in the 
      dampening inflammation and maintenance of tolerance.
FAU - Elkon, Keith B
AU  - Elkon KB
AD  - Department of Medicine and Immunology, University of Washington, Seattle, 
      Washington, USA. elkon@uw.edu
FAU - Silverman, Gregg J
AU  - Silverman GJ
LA  - eng
GR  - R01 AR48796/AR/NIAMS NIH HHS/United States
GR  - R01 NS065933/NS/NINDS NIH HHS/United States
GR  - R01AI068063/AI/NIAID NIH HHS/United States
GR  - R01AI090118/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 107-73-3 (Phosphorylcholine)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Autoantibodies/*immunology
MH  - Complement Activation/immunology
MH  - Complement System Proteins/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - *Immunity, Innate
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulin M/*immunology
MH  - Malondialdehyde/*immunology
MH  - Mice
MH  - Oxidation-Reduction
MH  - Phagocytosis/immunology
MH  - Phosphorylcholine/*immunology/metabolism
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_2 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:14-26. doi: 10.1007/978-1-4614-3461-0_2.