PMID- 22903667
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20171116
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Naturally occurring autoantibodies in mediating clearance of senescent red blood 
      cells.
PG  - 76-90
LID - 10.1007/978-1-4614-3461-0_6 [doi]
AB  - Germline-encoded naturally occurring autoantibodies (NAbs) developed about 400 to 
      450 million years ago to provide specificity for clearance ofbody waste in 
      animals with 3 germ layers. Such NAbs became a necessity to selectively clear 
      aged red blood cells (RBC) surviving 60 to 120 d in higher vertebrates. IgG NAbs 
      to senescent RBC are directed to the most abundant integral membrane protein, the 
      anion-transport protein or band 3 protein, but only bind firmly upon its 
      oligomerization, which facilitates bivalent binding. The main constituent of RBC, 
      the oxygen-carrying hemoglobin, is susceptible to oxidative damage. Oxidized 
      hemoglobin forms hemichromes (a form of aggregates) that bind to the cytoplasmic 
      portion of band 3 protein, induces their clustering on the cytoplasmic, as well 
      as the exoplasmic side and thereby provides the prerequisites for the low 
      affinity IgG anti-band 3 NAbs to bind bivalently. Bound anti-band 3 NAbs overcome 
      their low numbers per RBC by stimulating complement amplification. An affinity 
      for C3 outside the antigen binding region is responsible for a preferential 
      formation of C3b(2)-IgG complexes from anti-band 3 NAbs. These complexes first 
      bind oligomeric properdin, which enhances their affinity for factor B in 
      assembling an alternative C3 convertase.
FAU - Lutz, Hans U
AU  - Lutz HU
AD  - Institute of Biochemistry, Swiss Federal Institute of Technology, ETH 
      Honggerberg, Zurich, Switzerland. hans.lutz@bc.biol.ethz.ch
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Anion Exchange Protein 1, Erythrocyte)
RN  - 0 (Autoantibodies)
RN  - 0 (Complement C3)
RN  - 0 (Hemoglobins)
RN  - 0 (Immunoglobulin G)
RN  - EC 3.4.21.47 (Complement C3 Convertase, Alternative Pathway)
SB  - IM
MH  - Anion Exchange Protein 1, Erythrocyte/*immunology/metabolism
MH  - Autoantibodies/*immunology
MH  - Biological Evolution
MH  - Cellular Senescence/*immunology
MH  - Complement C3/immunology
MH  - Complement C3 Convertase, Alternative Pathway/immunology
MH  - Erythrocytes/cytology/*immunology
MH  - Hemoglobins/immunology/metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Immunoglobulin G/*immunology
MH  - Oxidation-Reduction
MH  - Protein Binding
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_6 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:76-90. doi: 10.1007/978-1-4614-3461-0_6.