PMID- 22903668
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Naturally occurring autoantibodies against beta-Amyloid.
PG  - 91-9
LID - 10.1007/978-1-4614-3461-0_7 [doi]
AB  - Naturally occurring antibodies (NAbs) have been described for more than 30 years. 
      Recently, NAbs against beta-Amyloid and against other proteins involved in 
      neurodegenerative disorders have been detected in humans. Based on the current 
      evidence, it is hypothesized that anti-Abeta NAbs can inhibit the fibrillation and 
      toxicity of beta-aymloid, can improve cognition in a transgenic mouse model and 
      interfere with oligomers of Abeta. Different functions of these NAbs have been 
      described in the current literature. Based on the results of the diverse studies 
      a Phase-III study using IVIG has been initiated in patients with AD. The results 
      will show whether the application of NAbs will change the fate of the disease. 
      This chapter summarizes our current knowledge on NAbs against Abeta.
FAU - Bach, Jan-Philipp
AU  - Bach JP
AD  - Department of Neurology, Philipps-University Marburg, Germany.
FAU - Dodel, Richard
AU  - Dodel R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Alzheimer Disease/immunology/*therapy
MH  - Amyloid beta-Peptides/*antagonists & inhibitors/immunology
MH  - Animals
MH  - Autoantibodies/*immunology/isolation & purification/metabolism
MH  - Clinical Trials as Topic
MH  - Cognition/drug effects
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulins, Intravenous/immunology/*therapeutic use
MH  - Mice
MH  - Mice, Transgenic
MH  - Plaque, Amyloid/immunology
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_7 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:91-9. doi: 10.1007/978-1-4614-3461-0_7.