PMID- 22903669
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Multi-faceted role of naturally occurring autoantibodies in fighting pathogens.
PG  - 100-13
LID - 10.1007/978-1-4614-3461-0_8 [doi]
AB  - Naturally occurring antibodies (NAbs) play a vital role in the first line of 
      defense against bacterial and viral infections. Most studies in mice and man have 
      attributed this role to NAbs of the IgM isotype. However, there is also a 
      significant amount of data on the anti-infectious function of NAbs of the IgG 
      isotype. Most of these observations are derived from studies using a privileged 
      source of NAbs, the pooled human IgG for intravenous application, IVIG. In 
      addition to its use as a replacement in humoral immunodeficiencies, IVIG is 
      extensively used in autoimmune and inflammatory diseases. The properties of NAbs, 
      the principal components of IVIG, are considered crucial for their 
      immune-regulatory properties, owing to their ability to recognize self-antigens 
      and even autoantibodies. By virtue of these specificities for several cellular 
      antigens, including exposed proteins that act as receptors for a variety of 
      pathogens, certain NAbs in IVIG have a therapeutic role in preventing or 
      modulating infections. We summarize in this chapter several examples that 
      highlight the importance of NAbs in the control of certain bacterial and viral 
      infections.
FAU - Bouhlal, Hicham
AU  - Bouhlal H
AD  - INSERM UMR 925, Amiens, France. hicham.bouhlal@u-picardie.fr
FAU - Kaveri, Srini
AU  - Kaveri S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Autoantibodies/*immunology
MH  - Autoantigens/immunology
MH  - Bacterial Infections/*drug therapy/immunology/microbiology
MH  - Clinical Trials as Topic
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
MH  - Immunoglobulin M/immunology
MH  - Immunoglobulins, Intravenous/administration & dosage/*immunology
MH  - Receptors, Virus/antagonists & inhibitors/*immunology
MH  - Virus Diseases/*drug therapy/immunology/virology
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_8 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:100-13. doi: 10.1007/978-1-4614-3461-0_8.