PMID- 22903670
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20211021
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Immunoregulation by naturally occurring and disease-associated autoantibodies : 
      binding to cytokines and their role in regulation of T-cell responses.
PG  - 116-32
LID - 10.1007/978-1-4614-3461-0_9 [doi]
AB  - The role of naturally occurring autoantibodies (NAbs) in homeostasis and in 
      disease manifestations is poorly understood. In the present chapter, we review 
      how NAbs may interfere with the cytokine network and how NAbs, through formation 
      of complement-activating immune complexes with soluble self-antigens, may promote 
      the uptake and presentation of self-molecules by antigen-presenting cells. Both 
      naturally occurring and disease-associated autoantibodies against a variety of 
      cytokines have been reported, including NAbs against interleukin (IL)-1alpha, IL-6, 
      IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon 
      (IFN)-alpha, IFN-beta, IFN-gamma, macrophage chemotactic protein-1 and IL-21. NAbs against a 
      variety of other self-antigens have also been reported, and using thyroglobulin 
      as an example we discuss how NAbs are capable of promoting uptake of immune 
      complexes via complement receptors and Fc-receptors on antigen-presenting cells 
      and thereby regulate T-cell activity. Knowledge of the influence of NAbs against 
      cytokines on immune homeostasis is likely to have wide-ranging implications both 
      in understanding pathogenesis and in treatment of many immunoinflammatory 
      disorders, including a number of autoimmune and autoinflammatory diseases.
FAU - Nielsen, Claus H
AU  - Nielsen CH
AD  - Institute for Inflammation Research, Department of Rheumatology, Copenhagen 
      University Hospital, Rigshospitalet, Copenhagen, Denmark. 
      claus.henrik.nielsen@rh.regionh.dk
FAU - Bendtzen, Klaus
AU  - Bendtzen K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Complement)
RN  - 0 (Receptors, Fc)
RN  - 9007-36-7 (Complement System Proteins)
RN  - 9010-34-8 (Thyroglobulin)
SB  - IM
MH  - Antigen-Presenting Cells/*immunology
MH  - Autoantibodies/*immunology/metabolism
MH  - Autoantigens/immunology
MH  - Autoimmune Diseases/immunology
MH  - Communicable Diseases/immunology
MH  - Complement Activation
MH  - Complement System Proteins/immunology
MH  - Cytokines/*immunology/metabolism
MH  - Humans
MH  - Inflammation/immunology
MH  - Protein Binding
MH  - Receptors, Complement/immunology/metabolism
MH  - Receptors, Fc/immunology/metabolism
MH  - T-Lymphocytes/*immunology
MH  - Thyroglobulin/immunology
PMC - PMC7123141
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
PMCR- 2020/04/03
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
PHST- 2020/04/03 00:00 [pmc-release]
AID - 9 [pii]
AID - 10.1007/978-1-4614-3461-0_9 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:116-32. doi: 10.1007/978-1-4614-3461-0_9.