PMID- 22903671
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20220317
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 750
DP  - 2012
TI  - Modulation of dendritic cells and regulatory T cells by naturally occurring 
      antibodies.
PG  - 133-44
LID - 10.1007/978-1-4614-3461-0_10 [doi]
AB  - Most studies on the effects of naturally occurring autoantibodies (NAbs) on 
      immune cells have been performed in the context of research on the 
      immunomodulatory effects of intravenous immunoglobulin (IVIG). Among others, IVIG 
      inhibits the differentiation, maturation and functions of dendritic cells (DC), 
      thereby suppressing T-cell activation. In addition, IVIG stimulates expansion and 
      suppressive function of regulatory T cells (Treg) carrying the antigens CD4, CD25 
      and Foxp3. Current data on the immunomodulatory effects of IVIG on DC and Treg 
      are summarized, and possible molecular interactions between NAbs and DC or Treg 
      that mediate these effects are discussed.
FAU - Kwekkeboom, Jaap
AU  - Kwekkeboom J
AD  - Laboratory of Gastroenterology and Hepatology, Erasmus MC - University Medical 
      Centre Rotterdam, The Netherlands. j.kwekkeboom@erasmusmc.nl
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Antigens, CD)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, Fc)
SB  - IM
MH  - Animals
MH  - Antigens, CD/immunology
MH  - Autoantibodies/*immunology
MH  - Cell Differentiation/immunology
MH  - Cell Proliferation
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immunoglobulins, Intravenous/immunology/therapeutic use
MH  - *Immunomodulation
MH  - Inflammation/drug therapy/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Receptors, Fc/immunology
MH  - T-Lymphocytes, Regulatory/cytology/*immunology
EDAT- 2012/08/21 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/978-1-4614-3461-0_10 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;750:133-44. doi: 10.1007/978-1-4614-3461-0_10.