PMID- 22905289
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1949-8454 (Electronic)
IS  - 1949-8454 (Print)
IS  - 1949-8454 (Linking)
VI  - 3
IP  - 6
DP  - 2012 Jun 26
TI  - Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on 
      mTORC1, mTORC2 and protein synthesis in myocytes.
PG  - 110-20
LID - 10.4331/wjbc.v3.i6.110 [doi]
AB  - Alcoholism and acquired immune deficiency syndrome are associated with severe 
      muscle wasting. This impairment in nitrogen balance arises from increased protein 
      degradation and a decreased rate of protein synthesis. The regulation of protein 
      synthesis is a complex process involving alterations in the phosphorylation state 
      and protein-protein interaction of various components of the translation 
      machinery and mammalian target of rapamycin (mTOR) complexes. This review 
      describes mechanisms that regulate protein synthesis in cultured C2C12 myocytes 
      following exposure to either alcohol or human immunodeficiency virus 
      antiretroviral drugs. Particular attention is given to the upstream regulators of 
      mTOR complexes and the downstream targets which play an important role in 
      translation. Gaining a better understanding of these molecular mechanisms could 
      have important implications for preventing changes in lean body mass in patients 
      with catabolic conditions or illnesses.
FAU - Hong-Brown, Ly Q
AU  - Hong-Brown LQ
AD  - Ly Q Hong-Brown, Abid A Kazi, Charles H Lang, Department of Cellular and 
      Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, United 
      States.
FAU - Kazi, Abid A
AU  - Kazi AA
FAU - Lang, Charles H
AU  - Lang CH
LA  - eng
GR  - R01 DK072909/DK/NIDDK NIH HHS/United States
GR  - R37 AA011290/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - World J Biol Chem
JT  - World journal of biological chemistry
JID - 101546471
PMC - PMC3421109
OTO - NOTNLM
OT  - AMP-activated protein kinase/tuberous sclerosis complex 2/Ras homolog enriched in 
      brain
OT  - Elongation
OT  - Mitogen-activated protein kinase
OT  - Phospholipase D
OT  - Rag GTPases
OT  - Translation initiation
EDAT- 2012/08/21 06:00
MHDA- 2012/08/21 06:01
PMCR- 2012/06/26
CRDT- 2012/08/21 06:00
PHST- 2011/12/22 00:00 [received]
PHST- 2012/05/29 00:00 [revised]
PHST- 2012/06/05 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/08/21 06:01 [medline]
PHST- 2012/06/26 00:00 [pmc-release]
AID - 10.4331/wjbc.v3.i6.110 [doi]
PST - ppublish
SO  - World J Biol Chem. 2012 Jun 26;3(6):110-20. doi: 10.4331/wjbc.v3.i6.110.