PMID- 22905805
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20121212
IS  - 1533-0338 (Electronic)
IS  - 1533-0338 (Linking)
VI  - 12
IP  - 1
DP  - 2013 Feb
TI  - Volumetric-modulated arc radiotherapy for skull-base and non-skull-base head and 
      neck cancer: a treatment planning comparison with fixed Beam IMRT.
PG  - 11-8
AB  - The purpose of this study is to compare the dose distribution, monitor units 
      (MUs) and radiation delivery time between volumetric-modulated arc (VMAT) and 
      fix-beam intensity modulated radiotherapy (FB-IMRT) in skull-base and 
      non-skull-base head and neck cancer (HNC). CT datasets of 8 skull-base and 7 
      non-skull-base HNC were identified. IMRT and VMAT plans were generated. The 
      prescription dose ranged 45-70 Gy (1.8-2.2 Gy/fraction). The VMAT delivery time 
      was measured when these plans were delivered to the patients. The FB-IMRT 
      delivery time was generated on a phantom. Comparison of dose-volume histogram 
      data, MUs, and delivery times was performed using T-test. Our results show that 
      both plans yield similar target volume coverage, homogeneity, and conformity. In 
      skull-base cases, compared to FB-IMRT, VMAT generated significantly smaller 
      hot-spot inside PTV (2.0% vs. 4.5%, p = 0.031), lower maximum chiasm dose (32 
      +/- 11 Gy vs. 41 +/- 15 Gy, p = 0.026), lower ipsilateral temporal-mandibular joint 
      dose (D33: 41.4 Gy vs. 46.1 Gy, p = 0.016), lower mean ipsilateral middle ear 
      dose (43 +/- 9 Gy vs. 38 +/- 10 Gy, p = 0.020) and a trend for lower optic nerve, 
      temporal lobe, parotid, and oral cavity dose. In non-skull-base cases, doses to 
      normal tissues were similar between the two plans. There was a reduction of 70% 
      in MUs (486 +/- 95 vs. 1614 +/- 493, p < 0.001) and 73% in delivery times (3.0 +/- 0.6 
      vs. 11.0 +/- 3.3 min, p < 0.001) favoring VMAT. We conclude that VMAT appears to 
      spare more normal tissues from high radiation dose for the tested skull-base 
      tumors. Dosimetrically, both approaches were equivalent for non-skull-base tumor 
      with VMAT using fewer MUs and shorter delivery time.
FAU - Chen, J
AU  - Chen J
AD  - Department of Radiation Oncology, Cancer Hospital of Shantou University Medical 
      College, Shantou, Guangdong, China.
FAU - Mok, E
AU  - Mok E
FAU - Wang, L
AU  - Wang L
FAU - Chen, C
AU  - Chen C
FAU - Le, Q-T
AU  - Le QT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120810
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Head and Neck Neoplasms/*radiotherapy
MH  - Humans
MH  - *Proton Therapy
MH  - Radiometry
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - *Radiotherapy, Intensity-Modulated
EDAT- 2012/08/22 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - product-p17981.html [pii]
AID - 10.7785/tcrt.2012.500251 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2013 Feb;12(1):11-8. doi: 10.7785/tcrt.2012.500251. 
      Epub 2012 Aug 10.