PMID- 22905988
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20161125
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 17
IP  - 8
DP  - 2012 Nov
TI  - Higher serum levels of soluble intracellular cell adhesion molecule-1 and soluble 
      vascular cell adhesion molecule predict peripheral artery disease in 
      haemodialysis patients.
PG  - 718-24
LID - 10.1111/j.1440-1797.2012.01654.x [doi]
AB  - AIM: Serum levels of soluble intracellular cell adhesion molecule-1 (sICAM-1), 
      soluble vascular cell adhesion molecule-1 (sVCAM) and monocyte chemotactic 
      protein 1 (MCP-1), are elevated in patients with peripheral artery disease (PAD). 
      However, the levels of these cell adhesion molecules in patients undergoing 
      haemodialysis (HD) are unclear. METHOD: A total of 112 HD patients were included 
      and PAD was diagnosed using the ankle-brachial index and Doppler ultrasound. 
      Serum levels of sICAM-1, sVCAM-1 and MCP-1 were assayed using enzyme linked 
      immunosorbent assay. RESULTS: Out of 106 HD patients, 31 (27.7%) were diagnosed 
      with PAD. After adjusting for risk factors, higher serum levels of sVCAM-1 and 
      sICAM-1 were associated with PAD in HD patients, with an odds ratio of 5.3 (95% 
      CI 3.3-65.5) and 2.7 (95% CI 1.2-21.8) respectively. Using sVCAM-1 and sICAM-1 
      for diagnosis of PAD in HD patients, sVCAM-1 had a sensitivity of 72.4% and 
      specificity of 62.3% for sVCAM-1 and sICAM-1 had a sensitivity of 89.3% and a 
      specificity of 40%. MCP-1 was not associated with PAD in HD patients. In 
      addition, the fistula of HD patients with PAD had a lower A-V access flow. 
      CONCLUSION: sVCAM-1 and sICAM-1 was associated with higher risk of PAD in HD 
      patients. Moreover, HD patients with PAD had a lower blood flow and lower A-V 
      access flow. Our results showed that sVCAM-1 and sICAM-1 may be used as screening 
      markers for PAD in HD patients.
CI  - (c) 2012 The Authors. Nephrology (c) 2012 Asian Pacific Society of Nephrology.
FAU - Cheng, Chi-Hung
AU  - Cheng CH
AD  - Institute of Medicine, Chung Shun Medical University, Department of Nephrology, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Chen, Yi-Shyan
AU  - Chen YS
FAU - Shu, Kuo-Hsiung
AU  - Shu KH
FAU - Chang, Horng-Rong
AU  - Chang HR
FAU - Chou, Ming-Chih
AU  - Chou MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (ICAM1 protein, human)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Ankle Brachial Index
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Chi-Square Distribution
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Peripheral Arterial Disease/blood/*diagnosis/diagnostic imaging
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - *Renal Dialysis
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Ultrasonography, Doppler
MH  - Up-Regulation
MH  - Vascular Cell Adhesion Molecule-1/*blood
EDAT- 2012/08/22 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1111/j.1440-1797.2012.01654.x [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2012 Nov;17(8):718-24. doi: 
      10.1111/j.1440-1797.2012.01654.x.